Hydrochloric Acid → HCID 20156716, Verbindung
Reaktionsgleichung
[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([C:10]1[CH:15]=[CH:14][C:13]([NH2:16])=[C:12]([CH:17]([CH3:19])[CH3:18])[CH:11]=1)([CH3:9])[CH3:8])[CH3:3].Cl>>[NH2:1][CH:2]([CH2:4][CH2:5][CH2:6][C:7]([CH:10]1[CH2:15][CH2:14][CH:13]([NH2:16])[CH:12]([CH:17]([CH3:19])[CH3:18])[CH2:11]1)([CH3:8])[CH3:9])[CH3:3]Komponenten
3
Versuchsvorschrift
5.2 Parts of 2-amino-6-(4-amino-3-isopropylphenyl)-6-methylheptane in 61 parts of 1N aqueous hydrochloric acid were hydrogenated at room temperature and atmospheric pressure using 1.0 parts of Nishimura catalyst. Thereafter at 7 and 24 hours respectively further 1.0 and 0.5 part additions of catalyst was made and the hydrogenation was complete after 46 hours with a 103% theory uptake. The work up followed Example 1, and gave, on distillation, 4.2 parts 2-amino-6-(4-amino-3-isopropylcyclohexyl)-6-methylheptane b12 182°-4° with the following percentage composition by weight.
Aufarbeitung
- customwere hydrogenated at room temperature
- customat 7 and 24 hours respectively further 1.0 and 0.5 part additions of catalyst