Sodium Hydroxide → 7-Aminocephalosporanic acid
Reaktionsgleichung
[OH-].[Na+].[CH3:3][C:4]([O:6][CH2:7][C:8]1[CH2:25][S:24][C@@H:11]2[C@H:12]([NH:15]C(CCCC(O)=O)=O)[C:13](=[O:14])[N:10]2[C:9]=1[C:26]([OH:28])=[O:27])=[O:5]>>[CH3:3][C:4]([O:6][CH2:7][C:8]1[CH2:25][S:24][C@@H:11]2[C@H:12]([NH2:15])[C:13](=[O:14])[N:10]2[C:9]=1[C:26]([OH:28])=[O:27])=[O:5]Komponenten
3
Versuchsvorschrift
CC Acylase immobilized on HPA 25 (20 mL) and prepared in the above-mentioned (2) was packed in a column with a jacket, and 6.0 mg/mL glutaryl 7-aminocephalosporanic acid (GL7-ACA) solution (100 mL) was circulated for one hour at 20° C. at circulation flow rate of about 70 mL/min while adjusting the pH to 7.75 with NaOH, whereby 7-ACA was obtained. After the reaction, the reaction mixture in the column was pushed out with water and 7-ACA was recovered. The above-mentioned reaction was repeated 100 times (continuous batch reaction), which was taken as one cycle.
Quellen und Nachweise
- ORD-Eintrag
- ord-3aea1b4596104c7698eac7029dfeb3f8
- Quelldatensatz
- uspto-grants-2003_10