Thionyl Chloride → 2-[(4-Dodecyloxyphenyl)sulfonyl]butanoyl Chloride

HRID 9871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 9871
[CH2:1]([O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH:23]([CH2:27][CH3:28])[C:24](O)=[O:25])(=[O:22])=[O:21])=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].S(Cl)([Cl:31])=O>C(OCC)(=O)C.CN(C)C=O>[CH2:1]([O:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([CH:23]([CH2:27][CH3:28])[C:24]([Cl:31])=[O:25])(=[O:22])=[O:21])=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

5

Edukt 2

HCID 24386Thionyl ChlorideHCID 155390142-[(4-Dodecyloxyphenyl)sulfonyl]butanoic acid

Produkt 1

HCID 155390152-[(4-Dodecyloxyphenyl)sulfonyl]butanoyl Chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

2-[(4-Dodecyloxyphenyl)sulfonyl]butanoic acid (1.1 g, 26.92 mMole) was suspended in ethyl acetate (100 mL) to which was added several drops of dimethylformamide and thionyl chloride (10.0 mL, 134.6 mMole). The mixture was heated at 70° C. for 1.5 hours, cooled, concentrated under reduced pressure, co-evaporated with ethyl acetate (2×100 mL) and the oil so obtained used as such in the next step of the reaction sequence.

Aufarbeitung

  1. temperaturecooled
  2. concentrationconcentrated under reduced pressure, co-evaporated with ethyl acetate (2×100 mL)
  3. customthe oil so obtained

Quellen und Nachweise

ORD-Eintrag
ord-8a5d47f9ffdd4f8e93a6b58ac33ac070
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07091361B2

Notizen zur Reaktion

Wird geladen…