Nitric Acid → 2,4,6-Trimethyl-3-nitrobenzoic acid

HRID 987846Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 987846
[CH3:1][C:2]1[CH:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[C:3]=1[C:4]([OH:6])=[O:5].[N+:13]([O-])([OH:15])=[O:14]>>[N+:13]([C:10]1[C:2]([CH3:1])=[C:3]([C:7]([CH3:12])=[CH:8][C:9]=1[CH3:11])[C:4]([OH:6])=[O:5])([O-:15])=[O:14]

Komponenten

3

Edukt 2

HCID 944Nitric AcidHCID 101942,4,6-Trimethylbenzoic acid

Produkt 1

HCID 81670772,4,6-Trimethyl-3-nitrobenzoic acidAusbeute 94 %

Versuchsvorschrift

To a suspension of 2,4,6-trimethylbenzoic acid (4.6 g, 28 mmol) in 70% HNO3 (85 mL) conc. H2SO4 (5 mL). was added dropwise at RT. The brown reaction mixture was stirred for 1 h, poured into ice-water (500 mL). The product was extracted into ethyl acetate, the extract was washed with water, dried over MgSO4 and concentrated to give 3-nitro-2,4,6-trimethylbenzoic acid as a yellow solid (6.7 g, 94%).

Aufarbeitung

  1. additionwas added dropwise at RT
  2. extractionThe product was extracted into ethyl acetate
  3. washthe extract was washed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-5bbccd3583664f3b86f56fdba47345ce
Quelldatensatz
uspto-grants-2003_10
Patentnummer
US06632829B2

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