Tetrahydro-4H-pyran-4-one → HCID 21906307, Verbindung
Reaktionsgleichung
Cl.[C:2](N)(=[O:9])[C:3]1C=C[CH:6]=[CH:5][CH:4]=1.FC(F)(F)C(O)=O.[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([NH:35][C:36]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[O:37])=[C:23]([CH:34]=1)[C:24]([NH:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=1)=[O:25].O1CCC(=O)CC1>>[ClH:18].[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([NH:35][C:36]([CH:38]2[CH2:39][CH2:40][N:41]([CH:4]3[CH2:3][CH2:2][O:9][CH2:6][CH2:5]3)[CH2:42][CH2:43]2)=[O:37])=[C:23]([CH:34]=1)[C:24]([NH:26][C:27]1[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][N:28]=1)=[O:25]Komponenten
4
Versuchsvorschrift
Using methods substantially equivalent to those described in example 27, 5-chloro-N-(5-chloropyridin-2-yl)-2-[1-(tetrahydropyran-4-yl)piperidin-4-ylcarbonyl]amino]-benzamide hydrochloride (0.25 g, 56%) was prepared from 5-chloro-N-(5-chloropyridin-2-yl)-2-[(piperidin-4-ylcarbonyl)amino]benzamide trifluoroacetate and tetrahydro-4H-pyran-4-one. The preparative RPHPLC (C18) purification procedure was elution with a linear gradient of 90/10 to 50/50 (0.01% HCl/acetonitrile) over 180 min.