Methanol → HCID 22348438, Verbindung
Reaktionsgleichung
C(O[C:4](=[O:17])[CH2:5][C:6]1([CH2:13][N+]([O-])=O)[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7]1)C.[CH3:18]O>[Ni]>[CH3:12][C:8]1([CH3:11])[CH2:9][CH2:10][C:6]2([CH2:5][C:4](=[O:17])[CH2:18][CH2:13]2)[CH2:7]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The ester 3 (380 mg, 1.6 mmol) and Raney Nickel (1 g) were suspended in methanol (75 mL) and shaken under a hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, the filtrate concentrated to give the lactam 4 (246 mg, 94%) as a white solid.
Aufarbeitung
- customThe catalyst was removed by filtration
- concentrationthe filtrate concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-17bb28d73ae04716ad41dbadd5ef01f5
- Quelldatensatz
- uspto-grants-2003_10
- Patentnummer
- US06635673B1
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