Ethyl 2-acetylhexanoate → HCID 178441161, Verbindung

HRID 989712

Reaktionsgleichung

Reaktionsgleichung von HRID 989712
[C:1]([CH:4]([CH2:10][CH2:11][CH2:12][CH3:13])[C:5](OCC)=[O:6])(=O)[CH3:2].C(=O)(O)O.[NH2:18][C:19]([NH2:21])=[NH:20]>C(O)C>[NH2:21][C:19]1[N:20]=[C:5]([OH:6])[C:4]([CH2:10][CH2:11][CH2:12][CH3:13])=[C:1]([CH3:2])[N:18]=1

Komponenten

4

Edukt 2

HCID 95466Ethyl 2-acetylhexanoateHCID 286947Carbonic acid-guanidine (1:1)

Produkt 1

HCID 178441161HCID 178441161, VerbindungAusbeute 47,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of ethyl 2-acetylhexanoate (5.59 g, 30 mmol), guanidine carbonate (6.49 g, 30 mmol) and ethanol (20 ml) was refluxed for 11 hours and then ice-cooled. The precipitated crystals were filtered, washed with ethanol and dried in vacuo to give 2-amino-5-butyl-6-methylpyrimidine-4-ol (2.59 g, 47%).

Aufarbeitung

  1. temperaturewas refluxed for 11 hours
  2. temperatureice-cooled
  3. filtrationThe precipitated crystals were filtered
  4. washwashed with ethanol
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-dc316f654fca4d58914fc8a2429549ab
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06458798B1

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