2,2-Difluoro-2-pyridin-2-ylethaneamine → N-(2,2-Difluoro-2-pyridin-2-yl-ethyl)-2-[3-(2,2-difluoro-2-pyridin-4-yl-ethylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-acetamide
Reaktionsgleichung
[F:1][C:2]([F:23])([C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1)[CH2:3][NH:4][C:5]1[C:6](=[O:16])[N:7]([CH2:12][C:13]([OH:15])=O)[C:8]([CH3:11])=[CH:9][N:10]=1.[F:24][C:25]([F:34])([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)[CH2:26][NH2:27]>>[F:34][C:25]([F:24])([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1)[CH2:26][NH:27][C:13](=[O:15])[CH2:12][N:7]1[C:8]([CH3:11])=[CH:9][N:10]=[C:5]([NH:4][CH2:3][C:2]([F:1])([F:23])[C:17]2[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=2)[C:6]1=[O:16]Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
N-(2,2-Difluoro-2-pyridin-2-yl-ethyl)-2-[3-(2,2-difluoro-2-pyridin-4-yl-ethylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-acetamide (6-3) 6-3 was prepared from [3-(2,2-difluoro-2-pyridin-4-ylethylamino)-6-methyl-2-oxo-2H-pyrazin-1-yl]-acetic acid and 2,2-difluoro-2-(2-pyridyl)ethyl amine essentially according to the procedure of Example 1, Step K. Mass Spectrum: Found: (M+1) 465.2.