Benzene, 1-iodo-4-(trifluoromethyl)- → 3-Isopropoxy-4-(4-trifluoromethyl-phenyl)-cyclobut-3-ene-1,2-dione

HRID 990768

Reaktionsgleichung

Reaktionsgleichung von HRID 990768
[CH:1]([O:4][C:5]1[C:6](=[O:23])[C:7](=[O:22])[C:8]=1[Sn](CCCC)(CCCC)CCCC)([CH3:3])[CH3:2].[F:24][C:25]([F:34])([F:33])[C:26]1[CH:31]=[CH:30][C:29](I)=[CH:28][CH:27]=1>>[CH:1]([O:4][C:5]1[C:6](=[O:23])[C:7](=[O:22])[C:8]=1[C:29]1[CH:30]=[CH:31][C:26]([C:25]([F:34])([F:33])[F:24])=[CH:27][CH:28]=1)([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 27366833-Isopropoxy-4-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione

Produkt 1

HCID 120516713-Isopropoxy-4-(4-trifluoromethyl-phenyl)-cyclobut-3-ene-1,2-dioneAusbeute 49,3 %

Versuchsvorschrift

In a manner similar to example 9, Step 1, 3-isopropoxy-4-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione (3.00 g, 6.99 mmol), 4-trifluoromethyl-iodobenzene (2.09 g, 7.69 mmol), benzylchlorobis(triphenylphos-phine)palladium (II) (0.318 g, 0.419 mmol) and cuprous iodide (0.12 g, 0.629 mmol) were reacted together to give 0.98 g (45%) of 3-isopropoxy-4-(4-trifluoromethyl-phenyl)-cyclobut-3-ene-1,2-dione which was of sufficient purity to use in the next step.

Quellen und Nachweise

ORD-Eintrag
ord-df8b6a18949441d3aa2f36e66eb7e0de
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06462059B1

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