Dimethylamine → 1-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantane

HRID 992164Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 992164
[CH3:1][NH:2][CH3:3].[CH3:4][O:5][C:6]([C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][C:10]([C:18]([O:20]C)=O)([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:7]>C1COCC1>[CH3:4][O:5][C:6]([C:8]12[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][C:10]([C:18](=[O:20])[N:2]([CH3:3])[CH3:1])([CH2:11]3)[CH2:9]1)[CH2:15]2)=[O:7]

Komponenten

4

Edukt 2

HCID 674DimethylamineHCID 365223Dimethyl 1,3-adamantanedicarboxylate

Produkt 1

HCID 184104771-(N,N-dimethylcarbamoyl)-3-methoxycarbonyladamantaneAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

1 mmole of 1,3-bis(methozxycarbonyl)adamantane obtained by the method of Example 84 was dissolved in 30 ml of THF. To the mixture, 0.5 mmole of dimethylamine and 0.1 mmole of aluminum chloride anhydride AlCl3 was added and reacted for 6 hours at 80° C. As a result, The conversion of 1,3-bis(methoxycarbonyl)adamantane was 90%, and 1-methoxycarbonyl-3-(N,N-dimethylcarbamoyl)adamantane (yield 80%) was formed.

Aufarbeitung

  1. customreacted for 6 hours at 80° C

Quellen und Nachweise

ORD-Eintrag
ord-412942a19b374c38be373ab763298900
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06468487B1

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