Tramadol → 2-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

HRID 992768

Reaktionsgleichung

Reaktionsgleichung von HRID 992768
[CH3:1][N:2]([CH2:4][C@@H:5]1[C@@:10]([OH:19])([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:3]>C(OCC)(=O)C>[CH3:3][N:2]([CH2:4][CH:5]1[C:10]([OH:19])([C:11]2[CH:12]=[C:13]([O:17][CH3:18])[CH:14]=[CH:15][CH:16]=2)[CH2:9][CH2:8][CH2:7][CH2:6]1)[CH3:1]

Komponenten

3

Edukt 1

HCID 33741Tramadol

Produkt 1

HCID 55232-((Dimethylamino)methyl)-1-(3-methoxyphenyl)cyclohexanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
-2.5 °C

Versuchsvorschrift

A reactor vessel is charged successively with cis-Tramadol base hydrate (crude) 200 Kg and ethyl acetate 300 l and the contents of the vessel heated to 50° l C. until all solids are in solution. The vessel is then cooled to −5 to 0° C. and the product crystallises. Stirring is continued for two hours and the product is then centrifuged and washed with cold ethyl acetate, 2×25 l. Approximately 165-175 Kg (moist) of cis(+/−) Tramadol base hydrate are obtained from this procedure.

Aufarbeitung

  1. temperaturethe contents of the vessel heated to 50° l C
  2. customthe product crystallises
  3. washwashed with cold ethyl acetate, 2×25 l

Quellen und Nachweise

ORD-Eintrag
ord-e8c097f866f144beb1946a20b872bfee
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06469213B1

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