Thionyl Chloride → HCID 12010380, Verbindung

HRID 992986Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 992986
O[CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:6][CH:7]=1.S(Cl)([Cl:22])=O>ClCCl>[Cl:22][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[C:12]([O:14][CH3:15])[C:11]([O:16][CH3:17])=[C:10]([O:18][CH3:19])[CH:9]=2)[S:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 18408501HCID 18408501, Verbindung

Produkt 1

HCID 12010380HCID 12010380, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

4-Hydroxymethyl-2-(3,4,5-trimethoxyphenyl)thiazole (2.0 g) was dissolved in dichloromethane (60 mL), and to the solution thionyl chloride (1.1 g) was added at 0° C. After 30 minutes, the mixture was warmed to room temperature and stirred for 4 hours. The reaction mixture was washed with water and saturated brine and dried over anhydrous sodium sulfate. After concentrating the reaction mixture under reduced pressure, the resultant crude crystals were recrystallized from chloroform-hexane to obtain the title compound.

Aufarbeitung

  1. washThe reaction mixture was washed with water and saturated brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. concentrationAfter concentrating the reaction mixture under reduced pressure
  4. customthe resultant crude crystals were recrystallized from chloroform-hexane

Quellen und Nachweise

ORD-Eintrag
ord-8adfac5c3aec49198ad8a4b90cf5a1db
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06472386B1

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