Hydrochloric Acid → 5-[3-(4-Methoxyphenyl)propionyl]barbituric acid

HRID 993051Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 993051
[NH:1]1[C:8](=[O:9])[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20](Cl)=[O:21])=[CH:14][CH:13]=1.Cl>N1C=CC=CC=1>[CH3:10][O:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][C:20]([CH:7]2[C:5](=[O:6])[NH:4][C:2](=[O:3])[NH:1][C:8]2=[O:9])=[O:21])=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6211Barbituric AcidHCID 109324413-(4-Methoxyphenyl)propionyl chloride

Produkt 1

HCID 140406695-[3-(4-Methoxyphenyl)propionyl]barbituric acidAusbeute 84,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a suspension of barbituric Acid (6.4 g) in 48 ml of pyridine are added dropwise 11 g of 3-(4-Methoxyphenyl)propionyl chloride and the mixture is stirred at room temperature for 18 hours. The reaction mixture is then poured into ice and acidified to pH=1 by adding 6 N hydrochloric acid. A solid precipitates, which is filtered and resuspended in methanol. The suspension is kept under stirring for 15 minutes, then the solid is recovered by filtration to give 12.2 g of the product m.p. 248-250° C.

Aufarbeitung

  1. additionThe reaction mixture is then poured into ice
  2. customA solid precipitates
  3. filtrationwhich is filtered
  4. stirringunder stirring for 15 minutes
  5. filtrationthe solid is recovered by filtration

Quellen und Nachweise

ORD-Eintrag
ord-636b6f65038640eebf739ef9c07fa20b
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06472396B1

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