Hydrochloric Acid → HCID 18677713, Verbindung

HRID 993202Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 993202
Cl.C([Cl:5])(=O)C.[CH2:6]([O:13][C:14]([N:16]([CH:20]1[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]1)[CH2:17][CH2:18][CH3:19])=[O:15])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(OCC)(=O)C>CO>[ClH:5].[CH2:6]([O:13][C:14]([N:16]([CH:20]1[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]1)[CH2:17][CH2:18][CH3:19])=[O:15])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 8857Ethyl AcetateHCID 186776841,1-Dimethylethyl 4-[[(phenylmethoxy)carbonyl]propylamino]-1-piperidinecarboxylate

Produkt 1

HCID 18677713HCID 18677713, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of 2.4 mmol of HCl in 2 mL of methanol (prepared by the addition of 0.17 mL of acetyl chloride at 0° C. and stirring for 10 min) was added 90 mg of 4-(N-(benzyloxycarbonyl)-N-(prop-1-yl)amino)-1-t-butoxycarbonylpiperidine. The mixture was stirred at rt for 16 h at which time the reaction was complete by TLC (20% ethyl acetate in hexanes) and was evaporated to dryness in vacuo to afford 75 mg of the title compound as the hydrochloride salt.

Aufarbeitung

  1. stirringThe mixture was stirred at rt for 16 h at which time the reaction
  2. customwas evaporated to dryness in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-85387509a08b413691e9e0bcd2878b61
Quelldatensatz
uspto-grants-2002_10
Patentnummer
US06472410B1

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