Basic information
- CAS
467-85-6- Standard SMILES
CCC(=O)C(CCN(C)C)(c1ccccc1)c1ccccc1- InChIKey
WCJFBSYALHQBSK-UHFFFAOYSA-N- Molecular formula
- C20H25NO
- Average molar mass
- 295.4 g/mol
- Monoisotopic mass
- 295.19361442
Overview
Normethadone is a diarylmethane.
Names & identifiers
- Preferred name
- Normethadone
- IUPAC
- 6-(dimethylamino)-4,4-diphenylhexan-3-one
- English name
- normethadone
- Molecular formula
- C20H25NO
- Molecular weight
- 295.42
Names & synonyms
NormethadoneMepidonIsomethadone IEucoponPhenyldimazoneHoechst 10582NormetadonaNormethadonumNormetadone6-Dimethylamino-4,4-diphenyl-3-hexanone467-85-6KR2L2A68XL
Show more names
Hoechst 10,582WCJFBSYALHQBSK-UHFFFAOYSA-N6-(Dimethylamino)-4,4-diphenyl-3-hexanone3-Hexanone, 6-(dimethylamino)-4,4-diphenyl-
6-(dimethylamino)-4,4-diphenylhexan-3-oneHOECHST-10582NSC-19598IDS-NN-007DTXSID6057748J5.915CDTXCID7031537nor-methadone
Database identifiers
- CAS
467-85-6- PubChem CID
- 10090
- DTXSID
DTXSID6057748- ChEMBL
CHEMBL346331- ChEBI
CHEBI:135242- UNII
- KR2L2A68XL
- EC Number
- 207-401-1
- Nikkaji
- J5.915C
Properties
Computed structural properties
- XLogP
- 3.5
- Topological polar surface area
- 20.3 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 7
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 320
Experimental & physicochemical properties
Drugs
DEA NFLIS-Drug Category -> Narcotic Analgesics
DEA Schedule I Controlled Substance -> Opiates
Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds
Pharmaceuticals -> Listed in ZINC15
LogP4.15
Endocrine DisruptorsPotential endocrine disrupting compound
Physicochemical properties
- Melting point
- 25 °C · <25 °C
- Boiling point
- 3 · bp3 164-167°
- Density
- 1.0389 · 1.0389 (rough estimate)
- refractive index
- 1.5614 · 1.5614 (estimate)
- pka
- 6 · pKa 6.00(50% aq EtOH) (Uncertain)
- FDA UNII
- 2 L2A68XL · KR2L2A68XL
- ATC code
- 5 DA06 · R05DA06
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Regulatory InformationDEA schedule I controlled substance
Chemistry & industry
Pharmacology
ATC Code
R - Respiratory system
QR - Respiratory system
PharmacodynamicsNormethadone is an opioid which suppresses coughing by central and peripheral mechanisms.
Mechanism of ActionNormethadone activates central opioid receptors in the medulla to supress the cough reflex. It also likely activates peripheral opioid receptors to inhibit signalling by irritant receptors of the airway.
MeSH Pharmacological Classification
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.
Upstream & downstream products
Upstream raw materials
Additional notes
DefinitionChEBI: Normethadone is a diarylmethane.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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