Dihydralazine

HCID 10230
NotesReactions
Substructure searchFind similar structures

Basic information

CAS
484-23-1
Standard SMILES
NNc1nnc(NN)c2ccccc12
InChIKey
VQKLRVZQQYVIJW-UHFFFAOYSA-N
Molecular formula
C8H10N6
Average molar mass
190.21 g/mol
Monoisotopic mass
190.09669434

Names & identifiers

Preferred name
Dihydralazine
IUPAC
(4-hydrazinylphthalazin-1-yl)hydrazine
English name
Dihydralazine
Molecular formula
C8H10N6
Molecular weight
190.21

Names & synonyms

DIHYDRALAZINE484-23-11,4-DihydrazinophthalazineDihydrallazinDihydrallazineHypopresol1,4-dihydrazinylphthalazineDihydrazinophthalazineDihidralazinaDihydralazinum2,3-Dihydro-1,4-phthalazinedione dihydrazoneC 7441
Show more names
c7441C8H1ON6nepresolOphthazintonolysinnepressolnepresolinNSC 526654
DTXSID00229351,4-Phthalazinedione, 2,3-dihydro-, dihydrazoneNSC-526654PCU411F5L6DTXCID902935NSC526654Dihydrazinophthalazindiidralazina

Database identifiers

CAS
484-23-1
PubChem CID
10230
DTXSID
DTXSID0022935
ChEMBL
CHEMBL35505
ChEBI
CHEBI:134841
UNII
PCU411F5L6
EC Number
207-605-0
Nikkaji
J5.994C

Properties

Computed structural properties

XLogP
0.2
Topological polar surface area
102 Ų
Hydrogen bond donors
4
Hydrogen bond acceptors
6
Rotatable bonds
2
Heavy atoms
14

Physicochemical properties

Melting point
180 °C · 180°C (rough estimate)
Boiling point
315.71 °C · 315.71°C (rough estimate)
Density
1.3243 · 1.3243 (rough estimate)
refractive index
1.81 · 1.8100 (estimate)
pka
3 · 3+-.0.20(Predicted)
color
2 O · Orange crystals from H2O

Safety & regulation

Hazard information

Other Safety InformationIMAP assessments - 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone: Environment tier I assessment；IMAP assessments - 1,4-Phthalazinedione, 2,3-dihydro-, dihydrazone: Human health tier I assessment

Safety data

hs_code
2933998090
Toxicity
LD50 i.p. in rats: 1084 mmol/kg (Steiner)
Signal word
Danger
Symbol(GHS)
GHS05
Hazard statements
H314
Precautionary statements
P280-P305+P351+P338-P310

Chemistry & industry

Pharmacology

ATC Code · 2 items

C - Cardiovascular system；C02 - Antihypertensives；C02D - Arteriolar smooth muscle, agents acting on；C02DB - Hydrazinophthalazine derivatives；C02DB01 - Dihydralazine

QC - Cardiovascular system；QC02 - Antihypertensives；QC02D - Arteriolar smooth muscle, agents acting on；QC02DB - Hydrazinophtalazine derivatives；QC02DB01 - Dihydralazine

MeSH Pharmacological Classification · 1 item

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Uses & manufacturing

UsesUse (kg; approx.) in Germany (2009): >500；Consumption (g per capita; approx.) in Germany (2009): 0.00611；Calculated removal (%): 75.1

Applications

UsesOphthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Preparation methods

PreparationDihydralazine is prepared from dichlorophthalazine via sequential substitution and hydrazination reactions. ​

Upstream & downstream products

Suppliers17 total

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
凯试(上海)科技有限公司021-50135380 · [email protected]

Additional notes

DefinitionChEBI: Dihydralazine is a member of phthalazines.

Related reactions

1 records
New reaction record

Compound notes

Loading…