CAS 72607-53-5 2-Propenamide, N-(3-aminopropyl)-2-methyl-, hydrochloride (1:1) (HCID 10375005)

Names & identifiers

Preferred name: 2-Propenamide, N-(3-aminopropyl)-2-methyl-, hydrochloride (1:1)
IUPAC: N-(3-aminopropyl)-2-methylprop-2-enamide;hydrochloride
English name: N-(3-Aminopropyl) methacrylamide
Molecular formula: C7H15ClN2O
Molecular weight: 178.66

Names & synonyms

N-(3-AMINOPROPYL)METHACRYLAMIDE HYDROCHLORIDE2-Propenamide, N-(3-aminopropyl)-2-methyl-, hydrochloride (1:1)RefChem:478837662-677-472607-53-5MFCD000782572-Propenamide, N-(3-aminopropyl)-2-methyl-, monohydrochlorideAPMAN-(3-AMINOPROPYL)METHACRYLAMIDE HCLN-(3-aminopropyl)-2-methylprop-2-enamide;hydrochlorideN-(3-AMINOPROPYL) METHACRYLAMIDE hydrochlorideN-(3-aminopropyl)-2-methylprop-2-enamide hydrochloride

Show more names

N-(3-Aminopropyl)-methacrylamideHClRiociguat Impurity 413-MethacrylamidopropylammonN-(3-Aminopropyl) methacrylamide3-Methacrylamidopropylammonium chloride.AMINOPROPYL)METHACRYLAMIDE HYDROCHLORIDEN-(3-Aminopropyl)methacrylamide hydrochloride,99%N-(3-Aminopropyl)methacrylamide hydrochloride,>98%N-(3-AMINOPROPYL) METHACRYLAMIDE ISO 9001：2015 REACH

SCHEMBL82715DTXSID3072581N-(3-aminopropyl)-2-methyl-prop-2-enamide HydrochlorideN-(3-aminopropyl)-2-methyl-prop-2-enamide;hydrochlorideN-(3-Aminopropylmethacrylamide HCl3-Methacrylamidopropylammonium ChlorideAKOS008901248N-(3-Aminopropyl)methacrylamide, HCl

Database identifiers

CAS: 72607-53-5
PubChem CID: 10375005
DTXSID: DTXSID3072581
EC Number: 662-677-4

Properties

Computed structural properties

Topological polar surface area: 55.1 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 2
Rotatable bonds: 4
Heavy atoms: 11
Formal charge: 0
Complexity: 132

Physicochemical properties

Melting point: 123 · 123-128°C
storage temp.: 2 · 2-8°C
form: powder
Appearance: White to off-white Solid
InChI: InChI=1S/C7H14N2O.ClH/c1-6(2)7(10)9-5-3-4-8;/h1,3-5,8H2,2H3,(H,9,10);1H
InChIKey: XHIRWEVPYCTARV-UHFFFAOYSA-N
SMILES: C(=O)(C(=C)C)NCCCN.Cl
EPA Substance Registry System: 2 · 2-Propenamide, N-(3-aminopropyl)-2-methyl-, monohydrochloride (72607-53-5)
UNSPSC Code: 12162002 · 12162002
NACRES: 23 · NA.23
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 319 · H319
Precautionary statements: 264 · P264-P280-P305+P351+P338-P337+P313
Hazard Codes: Xi
Risk Statements: 36 · 36/38
Safety Statements: 26 · 26
WGK Germany: 3 · 3
TSCA: TSCA listed
HS Code: 29241990 · 29241990
Storage Class: 11 · 11 - Combustible Solids
Hazard Classifications: 2 · Eye Irrit. 2

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H315 (97.6%): Causes skin irritation [Warning Skin corrosion/irritation]

P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)

Aggregated GHS information provided per 42 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory InformationPMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Hazard Classes and CategoriesSkin Irrit. 2 (97.6%)

Safety data

wgk: 3
tsca: TSCA listed
hs_code: 29241990
risk_code: 36/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26
Storage Class: 11 - Combustible Solids
Hazard statements: H319
Hazard Classifications: Eye Irrit. 2
Precautionary statements: P264-P280-P305+P351+P338-P337+P313

Chemistry & industry

Uses & manufacturing

General Manufacturing Information2-Propenamide, N-(3-aminopropyl)-2-methyl-, hydrochloride (1:1): ACTIVE

Applications · 2 items

UsesAPMA can be used in the preparation of copolymers and cross-linked miscellas for gene delivery, drug delivery and diagnostics applications.

General DescriptionN-(3-Aminopropyl)methacrylamide hydrochloride (APMA) is an aminoalkyl methacrylamide which can be synthesized by adding 1,3-diaminopropane to 1,3-diaminopropane dihydrogen chloride solution and further mixing the solution with methacrylic anhydride and hydroquinone. It has a primary amine that provides attractive features such as pH-responsiveness, affinity for anionic drugs and conjugation for variety of chemical structures.