Basic information
- CAS
52315-75-0- Standard SMILES
CCCCCCCCCCCC(=O)NCCCC[C@H](N)C(=O)O- InChIKey
GYDYJUYZBRGMCC-INIZCTEOSA-N- Molecular formula
- C18H36N2O3
- Average molar mass
- 328.5 g/mol
- Monoisotopic mass
- 328.27259301
Overview
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Lauroyl Lysine...
Names & identifiers
- Preferred name
- Lauroyl Lysine
- IUPAC
- (2S)-2-amino-6-(dodecanoylamino)hexanoic acid
- English name
- N'-Laruoyl-L-lysine
- Molecular formula
- C18H36N2O3
- Molecular weight
- 328.49
Names & synonyms
Lauroyl lysine52315-75-0L-Lysine, N6-(1-oxododecyl)-N6-Lauroyl-L-lysine(2S)-2-amino-6-(dodecanoylamino)hexanoic acidORISTAR LOLAMIHOPE LLlauroyllysineN6-(1-Oxododecyl)-L-lysineFAMEX L 12CORUM 5105LYSINE, N6-LAUROYL-, L-
Show more names
Laruoyl LysineN6-LauroyllysineNε-Lauroyllysine-Laruoyl-L-lysineN-LAUROYL-L-LYSINELysine Impurity 40N-Lauroyi-L-IysineNε-Lauroyl-L-Lys-OH
113171Q70BDTXSID80885998EINECS 257-843-4RefChem:798579LAUROYL LYSINE [INCI]DTXCID901025349n6-dodecanoyl-l-lysine(S)-2-Amino-6-dodecanamidohexanoic acid
Database identifiers
- CAS
52315-75-0- PubChem CID
- 104151
- DTXSID
DTXSID80885998- UNII
- 113171Q70B
- EC Number
- 257-843-4
Properties
Computed structural properties
- XLogP
- 2.2
- Topological polar surface area
- 92.4 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 16
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 309
Experimental & physicochemical properties
LipidsFatty Acyls [FA] -> Fatty amides [FA08] -> N-acyl amines [FA0802]
Cosmetics
Cosmetic ingredients (Lauroyl Lysine) -> CIR (Cosmetic Ingredient Review)
Hair conditioning; Skin conditioning; Viscosity controlling
Physicochemical properties
- Melting point
- 229 · 229-231 °C
- Boiling point
- 528 · 528.0±45.0 °C(Predicted)
- Density
- 0.994 · 0.994±0.06 g/cm3(Predicted)
- vapor pressure
- 0 · 0-0Pa at 20-50℃
- storage temp.
- 2 · 2-8°C
- pka
- 2.53 · 2.53±0.24(Predicted)
- form
- Powder
- color
- White to off-white
- Cosmetics Ingredients Functions
- HAIR CONDITIONINGVISCOSITY CONTROLLINGSKIN CONDITIONING
- Cosmetic Ingredient Review (CIR)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (151 of 151) of all reports.
Not Classified
Aggregated GHS information provided per 151 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: L-lysine, N(6) - (1-oxododecyl)
PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.
REACH registered substance: N6-(1-oxododecyl)-L-lysine (EC: 257-843-4)
L-Lysine, N6-(1-oxododecyl)-: Non hazardous
Hazard Classes and CategoriesNot Classified
Toxicology
Toxicity Summary
The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Lauroyl Lysine...
Safe for use in cosmetics, with qualifications
Safety data
- F
- 3-10
- wgk
- 3
- tsca
- TSCA listed
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Hazard statements
- H315-H319-H335
Chemistry & industry
Uses & manufacturing
UsesCIR ingredient: Lauroyl Lysine
Household ProductsInformation on 37 consumer products that contain Lauroyl lysine in the following categories is provided:
Use ClassificationCosmetics -> Hair conditioning; Skin conditioning; Viscosity controlling
General Manufacturing InformationL-Lysine, N6-(1-oxododecyl)-: ACTIVE
Applications
UsesLauroyl lysine (N6-Lauroyl-L-lysine) is a compound that can be synthesized by recombinant enzymes. After the synthase is cloned and expressed, it can be used to synthesize lauroyl lysine from specific raw materials with high yield.
Preparation methods
PreparationThe preparation of N'-Laruoyl-L-lysine is mainly achieved through a condensation reaction. In this process, amino acids and lauric acid are typically used as substrates, and the condensation reaction is carried out under enzymatic catalysis. The specific preparation process is as follows: First, amino acids and lauric acid are mixed in a certain proportion, and appropriate amounts of solvent and catalyst are added. Then, the reaction is carried out under suitable temperature and pH conditions. During the reaction, the ε-amino group of lysine undergoes a condensation reaction with the carboxyl group of lauric acid to generate N'-Laruoyl-L-lysine.
Upstream & downstream products
Downstream products
Suppliers100 total
Related reactions
2 records
Compound notes
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