2-Aminopyridine

Pyridinamine.

https://huagongshe.com/en/chemical/10439

Identifiers & Physical Properties

CAS No.	24843-39-8
Molecular formula	C5H6N2
Average molar mass	94.11 g/mol
Monoisotopic mass	94.05309819 g/mol
SMILES	Nc1ccccn1
InChIKey	ICSNLGPSRYBMBD-UHFFFAOYSA-N
PubChem CID	10439
ChEMBL	CHEMBL21619
EC No.	207-988-4
DTXSID	DTXSID0024505

Chemical & Physical Properties

XLogP	0.5
Topological polar surface area	38.9
Hydrogen bond donors	1
Hydrogen bond acceptors	2
Rotatable bonds	0
Heavy atoms	7
Formal charge	0
Complexity	54
Chemical classes	Nitrogen Compounds -> PyridinesFlammable agents - 2nd degree
pH	BASE
SpringerMaterials Properties	Molecular structure
LogP (partition coefficient)	log Kow= 0.480.49
Odor	Characteristic odor
Density	1.065 @ 20 °C/4 °C1.07 @25 °C1.0068 (rough estimate)
Color/Form	White leaflets or large colorless crystalsWHITE POWDER OR CRYSTALSWhite powder, leaflets, or crystals.Leaflets, or large crystals
Solubility	10 to 50 mg/mL at 66 °F (NTP, 1992)Soluble in alcohol, benzene, ether, and hot petrol ether>100 g/100 g water @ 20 °CSoluble in ethanol, ethyl ether, and acetoneWater solubility: >100g/100mL at 20 °CSolubility in water: very good
Flash point	198 °F (NTP, 1992)198 ° F68 °C, 154 °F (closed cup)68 °C c.c.
Boiling point	399 to 410 °F at 760 mmHg (NTP, 1992)210.6 °CBoiling point: 104-106 °C @ 20 mm Hg211 °C411 °F210.6 °C @760 [mm Hg]165.6°C (rough estimate)
Decomposition	DANGEROUSWHEN HEATED TO DECOMP IT EMITS HIGHLY TOXIC FUMES OF /NITROGEN OXIDES/.
Melting point	138 to 140 °F (NTP, 1992)58.1 °C58 °C137 °F
Refractive index	1.5000 (estimate)
EPA Substance Registry System	Pyridinamine (26445-05-6)

Safety & Regulations

Reactive group
GHS classification	This chemical does not meet GHS hazard criteria for 1.3% (2 of 156) of reports.DangerH301 (98.7%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 156 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatory information	Chemical: 2-PyridinamineStatus: Active Update: 25-02-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/215002-Aminopyridine: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT label	Poison
Fire hazards	This chemical is combustible. (NTP, 1992)Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:· Combustible material: may burn but does not ignite readily.Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air.
Health hazards	Excerpt from NIOSH Pocket Guide for 2-Aminopyridine:Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death.
Hazards summary	A chemical plant worker died after a spill which contaminated his clothing. He did not remove his clothing, and symptoms began about 2 hours after the exposure with headache and dizziness followed by respiratory distress and convulsions. [ACGIH] See Pyridine.
DOT ID and guide	2671 153

Applications & Uses

General Description

Aminopyridine is a white or clear colored crystalline solid. Pyridinamine. is soluble in water and alcohol. Pyridinamine. is toxic by ingestion and by inhalation of the dust. Pyridinamine. is used to make pharmaceuticals and dyes.