Basic information
- Standard SMILES
CNC.Cl- InChIKey
IQDGSYLLQPDQDV-UHFFFAOYSA-N- Molecular formula
- C2H7N.ClH
- Average molar mass
- 81.54 g/mol
- Monoisotopic mass
- 81.03452694
Names & identifiers
- Preferred name
- Dimethylamine, hydrochloride
- IUPAC
- N-methylmethanamine;hydrochloride
- English name
- Dimethylamine hydrochloride
- Molecular formula
- C2H8ClN
- Molecular weight
- 81.54
Names & synonyms
Dimethylamine hydrochloride506-59-2Dimethylammonium chlorideDimethylamine, hydrochlorideHydrochloric acid dimethylamine7M4CWB6AOKRefChem:588486208-046-5N-Methylmethanamine hydrochlorideMethanamine, N-methyl-, hydrochlorideDIMETHYLAMINE HClMFCD00012477
Show more names
METHANAMINE HYDROCHLORIDEDMAClMetformin impurity F CRSDiMethylaMine hydrochloridMetformin EP Impurity F HClJACS-506-59-2Dimethylamine hydrocImatinib EP Impurity I
C2H8ClNN,N-dimethylamine hydrochlorideDTXSID8027163N-methylmethanamine;hydrochlorideMethanamine, N-methyl-, hydrochloride (1:1)DIMETHYLAMINE-15-N HYDROCHLORIDEDimethyl amine hydrochloridedimethyl ammonium chloride
Database identifiers
- CAS
506-59-2- PubChem CID
- 10473
- DTXSID
DTXSID8027163- ChEMBL
CHEMBL569461- UNII
- 7M4CWB6AOK
- EC Number
- 208-046-5
Properties
Computed structural properties
- Topological polar surface area
- 12 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 0
- Heavy atoms
- 4
- Formal charge
- 0
- Complexity
- 2.8
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Amines, Aliphatic
Vapor Pressure0.000435 [mmHg]
Physical DescriptionDeliquescent solid; [Merck Index] White to off-white odorless solid; Hygroscopic; [Acros Organics MSDS]
Physicochemical properties
- Melting point
- 170 · 170-173 °C(lit.)
- Boiling point
- 95.79 °C · 95.79°C (rough estimate)
- Density
- 0.8949 · 0.8949 (rough estimate)
- bulk density
- 500 kg/m3 · 500kg/m3
- vapor pressure
- 0.1 hPa · <0.1 hPa (25 °C)
- refractive index
- 1.4202 · 1.4202 (estimate)
- storage temp.
- 30 °C · Store below +30°C.
- solubility
- 2 O: · H2O: soluble0.5g/10 mL
- form
- Crystalline Powder or Crystals
- color
- White to off-white
- PH
- 5 · 5 (100g/l, H2O, 20℃)
- Water Solubility
- 3000 g/L · 3000 g/L (20 ºC)
- Sensitive
- Hygroscopic
- Merck
- 14 · 14,3228
- BRN
- 3589311 · 3589311
- Stability
- Stable. Incompatible with strong oxidizing agents.
- InChI
- 1S/C2H7N.ClH/c1-3-2;/h3H,1-2H3;1H
- InChIKey
- IQDGSYLLQPDQDV-UHFFFAOYSA-N
- SMILES
- Cl[H].CNC
- LogP
- -3.28 · -3.28
- CAS DataBase Reference
- 506 · 506-59-2(CAS DataBase Reference)
- FDA UNII
- 7 M4CWB6AOK · 7M4CWB6AOK
- EPA Substance Registry System
- Methanamine, N-methyl-, hydrochloride (506-59-2)
- UNSPSC Code
- 12352107 · 12352107
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319
- Precautionary statements
- 264 · P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xn
- Risk Statements
- 22 · 22-36/37/38
- Safety Statements
- 26 · 26-36/37-37/39-36
- WGK Germany
- 1 · 1
- RTECS
- 220000 · IQ0220000
- F
- 3 · 3-9
- TSCA
- TSCA listed
- HS Code
- 29211190 · 29211190
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 4 OralEye · Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2
- Toxicity
- 50 in · LD50 in mice (g/kg): 1.21 i.v., 2.00 s.c. (Hazard); LC50 in mice (ppm): 7650 (48 hr), 4725 (14 day); in rats (ppm): 4540 (6 hr) (Steinhagen)
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
Warning
H302 (99.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 363 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Warning
H302: Harmful if swallowed [Warning Acute toxicity, oral]
Hazard information
Regulatory Information
Chemical: Methanamine, N-methyl-, hydrochloride
Status: Active Update: 17-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13403
Dimethylammonium chloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryAn irritant; Possible reproductive and fetal toxicant, based on animal studies; [Acros Organics MSDS] See Dimethylamine.
Hazard Classes and Categories
Acute Tox. 4 (99.7%)
Acute toxicity (Oral) - Category 4
Safety data
- F
- 3-9
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- IQ0220000
- hs_code
- 29211190
- Toxicity
- LD50 in mice (g/kg): 1.21 i.v., 2.00 s.c. (Hazard); LC50 in mice (ppm): 7650 (48 hr), 4725 (14 day); in rats (ppm): 4540 (6 hr) (Steinhagen)
- risk_code
- 22-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 26-36/37-37/39-36
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302-H315-H319
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2
- Precautionary statements
- P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
Chemistry & industry
Uses & manufacturing
Uses
Used as a rubber accelerator and in leather tanning; Also used to make detergents and as a boll weevil attractant; [Merck Index] Used as a catalyst for polymerization reactions, epoxy monomer for paints-coatings-thinners and polymers, to make fine and large scale chemicals, pharmaceuticals, and pesticides, and in electricity-steam-gas-water supply and sewage treatment; [ExPub: ECHA REACH Registrations]
Painting (Pigments, Binders, and Biocides) [Category: Paint]
General Manufacturing InformationMethanamine, N-methyl-, hydrochloride (1:1): ACTIVE
Applications
DescriptionDimethylamine hydrochloride is the raw material of organic synthesis, the catalyzer of analysis as an acetylize, and the preparation of azoviolet and dimethylamine aqueous solution. Dimethylamine hydrochloride deoxidation is very capable, and corrodibility is vital, so be usually used in cleaning-type soldering flux. Preparation technology is for slowly splashing into hydrochloric acid in dimethylamine for tradition, and the speed that splashes into is no more than 15 ℃ with temperature, and pH=7-8 is limited. After the reaction finishes, activated carbon decolorizing is added, the filtrate is adjusted to pH=3-4 with hydrochloric acid, decompression is steamed water to the greatest extent, obtaining dimethylamine hydrochloride.
UsesDimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.
UsesDimethylamine hydrochloride is a precursor to several industrially significant compounds.
UsesAs accelerator in vulcanizing rubber, tanning, manufacture of detergent soaps, or attracting boll weevils to exterminate them. As reagent for Mg.
Preparation methods
PreparationDimethylamine hydrochloride is obtained from the salt formation of dimethylamine and hydrochloric acid.
Upstream & downstream products
Upstream raw materials
Downstream products
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