Guanidine Nitrate

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

Use water in large amounts. In case of fire: keep drums, etc., cool by spraying with water.

Fresh air, rest.

First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.

· Keep combustibles (wood, paper, oil, etc.) away from spilled material.

Excerpt from ERG Guide 143 [Oxidizers (Unstable)]:

General First Aid:

If material on fire or involved in fire: Flood with water. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible.

Evacuation: If fire becomes uncontrollable - consider evacuation of one-half (1/2) mile radius.

Evacuate danger area and consult an expert in case of large spill. Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containers; if appropriate, moisten first to prevent dusting.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Evacuate danger area! Consult an expert! Do NOT wash away into sewer. Do NOT let this chemical enter the environment. Do NOT absorb in saw-dust or other combustible absorbents. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.

Methemoglobinemia can be treated with supplemental oxygen and methylene blue 1% solution administered intravenously slowly over five minutes followed by IV flush with normal saline. Methylene blue restores the iron in hemoglobin to its normal (reduced) oxygen-carrying state. (L1613)

LC50 Leuciscus idus (carp) 2420 mg/L/48 hr /Conditions of bioassay not specified in source examined/

LC50 Pimephales promelas (fathead minnow) 690 mg/L/96 hr; Conditions: flow-through, 20 to 22 °C

LC50 Ictalurus punctatus (channel catfish) 1850 mg/L/96 hr; Conditions: flow-through, 20 to 22 °C

EC50 Daphnia magna (water flea) 70.2 mg/L/48 hr; Conditions: 20 °C; Effect: immobilization test

For more Ecotoxicity Values (Complete) data for GUANIDINE, MONONITRATE (9 total), please visit the HSDB record page.

The substance can be absorbed into the body by ingestion.

Oral (L1137) ; inhalation (L1137)

Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as methemoglobinemia, and is characterized by tissue hypoxia, as methemoglobin cannot bind oxygen. (A2450, L1613)

Sore throat. Cough.

Redness. Pain.

Redness. Pain.

Nitrate and nitrite poisoning causes methemoglobinemia. Symptoms include cyanosis, cardiac dysrhythmias and circulatory failure, and progressive central nervous system (CNS) effects. CNS effects can range from mild dizziness and lethargy to coma and convulsions. (L1137)

/LABORATORY ANIMALS: Acute Exposure/ In rabbits administered 2,000 mg/kg bw by 24 hr semi-occlusive /dermal/ application, no substance-related deaths or clinical signs of toxicity were observed.

/LABORATORY ANIMALS: Acute Exposure/ The test material was described as slightly irritating to rabbit skin using the Draize method as prescribed in EPA Guideline (1982). Quantity applied: 2,000 mg/kg bw semiocclusively for 24 hr; after 0.5 hr erythema in 9/10 animals and edema in 2/10 animals. After 72 hr erythema in 2/10 animals without observation of edema.

/LABORATORY ANIMALS: Acute Exposure/ Described as highly irritating in the rabbit using the Draize method as described in EPA Guideline (1982). Application quantity: 500 mg; semiocclusive patch for 24 hr; after 14 days, 7/8 animals showed erythema; for edema after 24 hr 4/8 animals with an index of 1, 3/8 animals with an index of 2 and 1/8 with an index of 4; after 14 days no further edema was observed.

/LABORATORY ANIMALS: Acute Exposure/ Test material described as slightly irritating when applied to the skin /rabbit/ using OECD Guideline 404: Acute Dermal Irritation/Corrosion. Application amount: 500 mg; semiocclusive for 4 hours; slight erythema and edema in 1/3 animals after 1 hr.

For more Non-Human Toxicity Excerpts (Complete) data for GUANIDINE, MONONITRATE (8 total), please visit the HSDB record page.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/