Tetrahydrozoline Hydrochloride
Basic information
- CAS
522-48-5- Standard SMILES
Cl.c1ccc2c(c1)CCCC2C1=NCCN1- InChIKey
BJORNXNYWNIWEY-UHFFFAOYSA-N- Molecular formula
- C13H17ClN2
- Average molar mass
- 236.74 g/mol
- Monoisotopic mass
- 236.1080262
Overview
Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline(1+).
Names & identifiers
- Preferred name
- Tetrahydrozoline Hydrochloride
- IUPAC
- 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride
- English name
- 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
- Molecular formula
- C13H16N2.ClH
- Molecular weight
- 236.74
Names & synonyms
Tetrahydrozoline hydrochloride522-48-5Tetrahydrozoline HClTetryzoline hydrochlorideTyzineVasoposTyzanol hydrochlorideRhinoprontDTXSID70453160YZT43HS7DNSC-7573392-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride
Show more names
TetrahydrozlineTetrahydrozoline hyrdrochlorideTETRAHYDROZOLINEHYDROCHLORIDE,USPTetrahydrozoline·hydrochloric acidTetrahydrozoline Hydrochloride (200 mg)SootheTizine
2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline monohydrochloride1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochlorideCHEBI:9492DTXCID5025316Redness RelieverT-raojoEquate Eye DropsDg Health Original
Database identifiers
- CAS
522-48-5- PubChem CID
- 10648
- DTXSID
DTXSID7045316- ChEMBL
CHEMBL1200413
Properties
Computed structural properties
- Topological polar surface area
- 24.4 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 1
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 259
Experimental & physicochemical properties
Solubility>35.5 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section145.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 248 · 248-251°C
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- 2 O: · H2O: freely soluble
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 2 O: · H2O: freely solublealcohol: freely solublechloroform: very slightly solublediethyl ether: insoluble
- InChI
- InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
- InChIKey
- BJORNXNYWNIWEY-UHFFFAOYSA-N
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Other Safety InformationIMAP assessments - 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- NJ4550000
- hs_code
- 2933290000
- risk_code
- 22-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn,Xi
- safety_code
- 26-36
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
Uses & manufacturing
General Manufacturing Information1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1): ACTIVE
Applications
Usesadrenergic agonist, nasal decongestant
UsesAn alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.
Uses2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride is an alpha agonist, causing constriction of conjunctival blood vessels,it is used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.
Upstream & downstream products
Upstream raw materials
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Compound notes
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