Cefotaxime Sodium

ctx · CEFOTAXIME SODIUM STERILE · CEFOTAXIME SODIUM SALT · CLAFORAN · Sodium cefotaxime · CEFOTAXIME NA-SALT · Cefotaxime free acid · CEFOTAXIM SODIUM SALT

https://huagongshe.com/en/chemical/10695961

Identifiers & Physical Properties

CAS No.	64485-93-4
Molecular formula	C16H16N5NaO7S2
Average molar mass	477.5 g/mol
Monoisotopic mass	477.03888413 g/mol
SMILES	CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(COC(C)=O)CS[C@H]12)c1csc(N)n1.[Na+]
InChIKey	AZZMGZXNTDTSME-JUZDKLSSSA-M
PubChem CID	10695961
ChEMBL	CHEMBL1010
ChEBI	CHEBI:3498
EC No.	264-915-9
DTXSID	DTXSID4046991

Chemical & Physical Properties

Topological polar surface area	230
Hydrogen bond donors	2
Hydrogen bond acceptors	12
Rotatable bonds	8
Heavy atoms	31
Formal charge	0
Complexity	839
Solubility	68.2 [ug/mL] (The mean of the results at pH 7.4)H2O: aqueous solutions of pH 4.3-6.2 are stable up to 3 weeks at 2-8 °C.solubleSoluble in water.
Human Drugs	FDA approved drugs -> Active ingredient
Melting point	162-163 C
alpha	D20 +55±2° (c = 0.8 in water)
Refractive index	61 ° (C=1, H2O)
Storage conditions	Keep in dark place,Inert atmosphere,2-8°C
Physical state	powder
Color	white to yellow
pH	pH(100g/l, 25℃) : 4.5～6.5
optical activity	[α]/D +58 to +64°, c =1 in H2O
Merck	14,1933
BRN	5711411
Stability	Stable. Incompatible with strong oxidizing agents.
InChIKey	ACGQSCNTUWPWNB-RRVHIMMXNA-N
SMILES	C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3=CSC(N)=N3)=N\OC)C(=O)N12)COC(=O)C)(=O)O.[NaH] \|&1:5,7,r\|
NCI Dictionary of Cancer Terms	CTX
FDA UNII	258J72S7TZ
NCI Drug Dictionary	Claforan
UNSPSC Code	12352200
NACRES	NA.72
GHS pictogram	GHS08
Signal word	Danger
GHS hazard statements	H317-H334
GHS precautionary statements	P261-P280-P284-P304+P340-P333+P313-P342+P311
Hazard symbols	Xn,Xi
Risk statements (R)	42/43
Safety statements (S)	22-36/37-60-45-37-24
Water hazard class (WGK)	2
RTECS number	XI0250000
Customs code	29419000
Storage class	11 - Combustible Solids
Hazard class	Resp. Sens. 1Skin Sens. 1

Safety & Regulations

GHS classification	DangerH317 (99.2%): May cause an allergic skin reaction [Warning Sensitization, Skin]P233, P260, P261, P271, P272, P280, P284, P302+P352, P304+P340, P321, P333+P317, P342+P316, P362+P364, P403, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 132 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Regulatory information	Cefotaxime sodium: Does not have an individual approval but may be used under an appropriate group standard
Hazard Classes and Categories	Skin Sens. 1 (99.2%)
Drug Induced Liver Injury	Drug Induced Liver Injury Rank (DILIrank 2.0)Cefotaxime sodiumvLess-DILI-concern5Adverse reactionsDOI:10.1016/j.drudis.2016.02.015
Water hazard class (WGK)	2
RTECS number	XI0250000
Customs code	29419000
Risk statements (R)	42/43
Signal word	Danger
GHS pictogram	GHS08
Hazard symbols	Xn,Xi
Safety statements (S)	22-36/37-60-45-37-24
Storage class	11 - Combustible Solids
GHS hazard statements	H317-H334
Hazard class	Resp. Sens. 1Skin Sens. 1
GHS precautionary statements	P261-P280-P284-P304+P340-P333+P313-P342+P311

Applications & Uses

Description

Cefotaxime was synthesized by Hoechst and Roussel-Uclaf in 1977. It was the first derivative of cephalosporin to introduce the methoxyimino and aminothiazole groups at the 7 position of the cephem nucleus. Although it shows unexpectedly low oral absorption, its excellent activity against a wide range of gram-positive and gram-negative organisms, including Serratia, Enterobacter, Citrobacter, and anaerobes, guided research and development of the newer synthetic cephems, the so-called thirdgeneration cephalosporins.

Uses

Broad spectrum third generation cephalosporin antibiotic. The name Cefotaxime applies to the isomer having a syn-methoxy imino group

Uses

Cephalosporin antibacterial

Uses

Cefotaxime sodium salt acts as a beta-lactamase resistant antibiotic. It is used as an effective antibacterial against gram-negative bacteria, with the notable exception of pseudomonas and penicillin-resistant strains of streptococcus pneumoniae. It is used to treat infections of the bones, joints, skin, respiratory tract and blood stream.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards