Betaxolol Hydrochloride

HCID 107952

Basic information

CAS
63659-19-8
Standard SMILES
CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1.Cl
InChIKey
CHDPSNLJFOQTRK-UHFFFAOYSA-N
Molecular formula
C18H30ClNO3
Average molar mass
343.9 g/mol
Monoisotopic mass
343.1914215

Overview

Betaxolol Hydrochloride is the hydrochloride salt form of betaxolol, a beta-1-selective adrenergic receptor antagonist without intrinsic sympathomimetic activity. Betaxolol hydrochloride acts on the heart and circulatory system and decreases cardiac contractility and rate, thereby reducing cardiac output. When applied topically in the eye, it lowers intraocular pressure by reducing aqueous humor secretion.

Names & identifiers

Preferred name
Betaxolol Hydrochloride
IUPAC
1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol;hydrochloride
English name
Betaxolol hydrochloride
Molecular formula
C18H30ClNO3
Molecular weight
343.89

Names & synonyms

Betaxolol hydrochloride63659-19-8Betaxolol HCLBetoptic SNSC-7600486X97D2XT0OALO-140102ALO-1401-02SL-7521210DTXSID30979876SL-75.212-101-(Isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol hydrochloride
Show more names
SL 75212Kerlonkerlonebetopticsl-d.212BetaxoloBetoptimasl75212-10SL 75212 HCl
SL-75212-10CHEBI:6432281-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol hydrochloride1-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)-3-(propan-2-ylamino)propan-2-ol hydrochlorideHydrochloride, BetaxololRefChem:56624DTXCID401407156ALO140102

Database identifiers

CAS
63659-19-8、72424-72-7
PubChem CID
107952
DTXSID
DTXSID30979876
ChEMBL
CHEMBL1691
UNII
6X97D2XT0O
EC Number
264-384-3

Properties

Computed structural properties

Topological polar surface area
50.7 Ų
Hydrogen bond donors
3
Hydrogen bond acceptors
4
Rotatable bonds
11
Heavy atoms
23

Experimental & physicochemical properties

Human Drugs · 2 items

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physicochemical properties

Melting point
116 ° · 116°
storage temp.
2 · 2-8°C
solubility
2 O: · H2O: 36 mg/mL, soluble
form
solid
color
white
Water Solubility
50 mM · Soluble to 50 mM in water

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 2% (1 of 49) of reports.

Warning

H302 (98%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 49 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (98%)

Toxicology

Drug Induced Liver Injury · 6 items

Drug Induced Liver Injury Rank (DILIrank 2.0)

Betaxolol hydrochloride

Ambiguous-DILI-concern

3

Adverse reactions

DOI:10.1016/j.drudis.2016.02.015

Safety data

wgk
3
rtecs
UA9823000
hs_code
2922504500
Toxicity
LD50 in mice (mg/kg): 944 orally; 37 i.v. (Manoury)
risk_code
22
Signal word
Warning

Chemistry & industry

Pharmacology

FDA Pharmacological Classification · 2 items

BETAXOLOL HYDROCHLORIDE

Adrenergic beta-Antagonists [MoA]; beta-Adrenergic Blocker [EPC]

MeSH Pharmacological Classification · 3 items

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.

Drugs that bind to and block the activation of ADRENERGIC BETA-1 RECEPTORS.

Applications · 4 items

DescriptionBetaxolol (hydrochloride) (Item No. 26285) is an analytical reference standard categorized as a β1-adrenergic receptor antagonist. Formulations containing β-adrenergic receptor antagonists have been used to enhance physical performance in athletes. This product is intended for use in analytical forensic applications. This product is also available as a general research tool .

DescriptionBetaxolol hydrochloride is a cardioselective β-adrenergic blocker, reportedly devoid of intrinsic sympathomimetic and membrane stabilizing properties. Its long duration of action permits once-daily dosing in mild to moderate hypertension. It is also being evaluated in glaucoma.

Usesantifungal

UsesBetaxolol Hydrochloride, a cardioselective β1-adrenergic blocker. An antihypertensive; antiglaucoma.

Suppliers100 total

安徽省庆云医药股份有限公司[email protected]
国药集团化学试剂有限公司86-21-63210123 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
盐城通铭生物科技有限公司15195160625 · [email protected]

Additional notes

DefinitionChEBI: The hydrochloride salt of betaxolol.

Related reactions

2 records

Compound notes

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