Basic information
- CAS
55804-65-4- Standard SMILES
O=C(O)c1cc2cc3c4c(c2oc1=O)CCCN4CCC3- InChIKey
KCDCNGXPPGQERR-UHFFFAOYSA-N- Molecular formula
- C16H15NO4
- Average molar mass
- 285.29 g/mol
- Monoisotopic mass
- 285.10010796
Names & identifiers
- Preferred name
- Coumarin 343
- IUPAC
- 4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carboxylic acid
- English name
- Coumarin 343
- Molecular formula
- C16H15NO4
- Molecular weight
- 285.29
Names & synonyms
Coumarin 34355804-65-47GE3Q7LWR9CHEBI:519412,3,6,7-tetrahydro-11-oxo-1h,5h,11h-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acidDTXSID90690511H,5H,11H-(1)Benzopyrano(6,7,8-ij)quinolizine-10-carboxylic acid, 2,3,6,7-tetrahydro-11-oxo-2,3,6,7-Tetrahydro-11-oxo-1H,5H,11H-(1)benzopyrano(6,7,8-ij)quinolizine-10-carboxylic acid1H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acid, 2,3,6,7-tetrahydro-11-oxo-RefChem:579303DTXCID6041973259-824-6
Show more names
C-343KMG-20COUMARIN(RG)Coumarine 343RARECHEM AL BO 1145Exciton Coumarin 519COUMARIN 343 (2 GMS)Coumarin343lasergrade
11-oxo-2,3,5,6,7,11-Hexahydro-1H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-10-carboxylic acidCoumarin 519Coumarin 343 acidMFCD0005133511-oxo-2,3,6,7-tetrahydro-1H,5H,11H-pyrano[2,3-f]pyrido[3,2,1-ij]quinoline-10-carboxylic acid1h,5h,11h-[1]benzopyrano[6,7,8-ij]quinolizine-10-carboxylicacid, 2,3,6,7-tetrahydro-11-oxo-4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carboxylic acidCHEMBL2442512
Database identifiers
- CAS
55804-65-4- PubChem CID
- 108770
- DTXSID
DTXSID9069051- ChEMBL
CHEMBL2442512- ChEBI
CHEBI:51941- UNII
- 7GE3Q7LWR9
- EC Number
- 259-824-6
- Nikkaji
- J296.501A
Properties
Computed structural properties
- XLogP
- 3.1
- Topological polar surface area
- 66.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 1
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 514
Physicochemical properties
- Melting point
- 240 °C · 240 °C(lit.)
- Boiling point
- 574.8 · 574.8±50.0 °C(Predicted)
- Density
- 1.47 · 1.47±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- 0.1 · Chloroform: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
- pka
- -98.22 · -98.22±0.20(Predicted)
- form
- Crystalline Powder
- color
- Orange
- λmax
- 443 nm · 443 nm
- ε(extinction coefficient)
- 26000 at · ≥26000 at 441-445nm in ethanol at 0.01g/L
- Major Application
- diagnostic assay manufacturinghematologyhistology
- InChI
- InChI=1S/C16H15NO4/c18-15(19)12-8-10-7-9-3-1-5-17-6-2-4-11(13(9)17)14(10)21-16(12)20/h7-8H,1-6H2,(H,18,19)
- InChIKey
- KCDCNGXPPGQERR-UHFFFAOYSA-N
- SMILES
- C12=C3OC(=O)C(C(O)=O)=CC3=CC3=C1N(CCC3)CCC2
- FDA UNII
- 7 GE3Q7LWR9 · 7GE3Q7LWR9
- EPA Substance Registry System
- 1 H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizine-10-carboxylic · 1H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acid, 2,3,6,7-tetrahydro-11-oxo- (55804-65-4)
- UNSPSC Code
- 12171500 · 12171500
- NACRES
- 47 · NA.47
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319-H315
- Precautionary statements
- 264 · P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Hazard Codes
- Xn
- Risk Statements
- 36 · 36/37/38-20/21/22
- Safety Statements
- 37 · 37/39-26-24/25
- WGK Germany
- 3 · 3
- TSCA
- TSCA listed
- HS Code
- 29349990 · 29349990
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
GHS classification
GHS Classification
Warning
H302 (50%): Harmful if swallowed [Warning Acute toxicity, oral]；H312 (50%): Harmful in contact with skin [Warning Acute toxicity, dermal]；H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H332 (50%): Harmful if inhaled [Warning Acute toxicity, inhalation]；H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (50%)；Acute Tox. 4 (50%)；Skin Irrit. 2 (100%)；Eye Irrit. 2 (100%)；Acute Tox. 4 (50%)；STOT SE 3 (50%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- TSCA listed
- hs_code
- 29349990
- risk_code
- 36/37/38-20/21/22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 37/39-26-24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H319-H315
- Precautionary statements
- P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Chemistry & industry
Uses & manufacturing
General Manufacturing Information1H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizine-10-carboxylic acid, 2,3,6,7-tetrahydro-11-oxo-: ACTIVE
Applications
DescriptionCoumarin 519 is a synthetic fluorescent dye widely used in biomedical research. It serves as a valuable tool for studying drug distribution and pharmacokinetics, as well as for monitoring membrane potential and calcium signaling in live cells. Additionally, it finds applications in fluorescence microscopy, flow cytometry, and bioimaging techniques.
UsesSuitable as a laser dye.
Upstream & downstream products
Upstream raw materials
Suppliers97 total
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
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Additional notes
DefinitionChEBI: Coumarin 343 is a member of 7-aminocoumarins. It has a role as a fluorochrome.
Related reactions
4 records
Compound notes
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