2-Bromoethanol

HCID 10898CAS 29155-34-8

Basic information

Standard SMILES
OCCBr
InChIKey
LDLCZOVUSADOIV-UHFFFAOYSA-N
Molecular formula
C2H5BrO
Average molar mass
124.96 g/mol
Monoisotopic mass
123.95237688

Overview

2-bromoethanol is a colorless to dark brown liquid. Sweet burning taste. (NTP, 1992)

Names & identifiers

Preferred name
2-Bromoethanol
IUPAC
2-bromoethanol
English name
2-Bromoethanol
Molecular formula
C2H5BrO
Molecular weight
124.96

Names & synonyms

2-BROMOETHANOL540-51-2Ethylene bromohydrinEthanol, 2-bromo-BromoethanolGlycol bromohydrin2-Hydroxyethyl bromide1-Bromo-2-ethanolEthylenebromohydrin2-Bromoethyl alcoholNSC-2869Z33995S34R
Show more names
2-BromethanolDKSI056HO-PEG1-BrDKFELEX0079BROMOETHANOL-2
beta-bromoethyl alcoholRefChem:596595208-748-12-bromoethan-1-ol2-Bromo-1-ethanolDTXSID80202002-bromo-ethanolC2H5BrO

Database identifiers

CAS
29155-34-8、540-51-2
PubChem CID
10898
DTXSID
DTXSID8020200
ChEMBL
CHEMBL468583
UNII
Z33995S34R
EC Number
208-748-1
Nikkaji
J1.597K

Properties

Computed structural properties

XLogP
0.2
Topological polar surface area
20.2 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
1
Rotatable bonds
1
Heavy atoms
4

Experimental & physicochemical properties

Chemical ClassesOther Classes -> Halogenated Alcohols
SpringerMaterials PropertiesSchoenflies notation
Density · 2 items

1.7629 at 68 °F (NTP, 1992) - Denser than water; will sink

1.7629 @ 20°C

Solubility10 to 50 mg/mL at 66 °F (NTP, 1992)
Flash Point · 2 items

105 °F (NTP, 1992)

105 °F

Boiling Point · 2 items

300 to 302 °F at 750 mmHg (Decomposes) (NTP, 1992)

150 °C @760 [mm Hg]

Physicochemical properties

Melting point
-80 °C · -80 °C
Boiling point
56 · 56-57 °C/20 mmHg (lit.)
Density
1.763 g/mL · 1.763 g/mL at 25 °C (lit.)
vapor density
4.3 · 4.3 (vs air)
vapor pressure
2.4 mm · 2.4 mm Hg ( 20 °C)
refractive index
20 · n20/D 1.492(lit.)

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H301 (95.5%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P262, P264, P270, P271, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 111 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 3 items

Chemical: Ethanol, 2-bromo-

Status: Active Update: 10-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23691

2-Bromoethanol: Does not have an individual approval but may be used under an appropriate group standard

DOT LabelFlammable Liquid
Fire HazardsThis compound is combustible. (NTP, 1992)
Health HazardsSYMPTOMS: Vapors cause irritation to eyes and mucous membranes as well as headache, respiratory distress, and loss of consciousness. Ingestion has similar effects plus nausea and vomiting. Contact with the skin may cause severe dermatitis.
Hazards Summary · 1 item

Highly toxic; [Quick CPC] Corrosive to the skin, eyes, and respiratory tract, it may cause chemical pneumonitis. [CHEMINFO MSDS] A skin and eye irritant and may be corrosive; Inhalation of vapors may cause loss of consciousness and respiratory distress; [CAMEO]

Reactive GroupAlcohols and Polyols

Safety & protection

Fire FightingFires involving this compound can be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
Protective Action Criteria (PAC) · 3 items

0.35 [mg/m3]

3.8 [mg/m3]

23 [mg/m3]

Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Toxicology

Adverse EffectsDermatotoxin - Skin burns.

Safety data

PPE
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk
3
tsca
TSCA listed
rtecs
KJ8225000
ridadr
UN 2922 8/PG 2
hs_code
29055900

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationEthanol, 2-bromo-: ACTIVE
Applications · 3 items

Description2-bromoethanol, a halogenated alipathic hydrocarbon, is a widely used industrial chemical. It is also a contaminant in food such as wheat and flour during treatment with ethylene oxide. 2-Bromoethanol was also found as a metabolite of 1,2-dibromoethane. A known carcinogen in experimental animals. 2-Bromoethanol is highly toxic in vivo and is a potent mutagen. Fatty acid conjugates of 2-bromoethanol that have been identified after 2-bromoethanol administration to rats may explain the long term 2-bromoethanol accumulation and retention in body tissues. Chronic exposure to 2-bromoethanol causes liver and kidney toxicity. 2- Bromoethanol also induces extensive lipid peroxidation in rat liver, kidney and testis slices and inhibits liver mitochondria respiration[1].

Uses2-Bromoethanol is used in selective reduction of nitroarenes (PcFe(II)/NaBH4/2-bromoethanol catalyst system). It is not used much forany commercial purpose. The risk of exposure to this compound arises when ethylene oxide reacts with hydrobromic acid. It is used as a solvent and organic synthetic raw material. 2-Bromoethanol finds application in the synthesis of 2-piperidin-1-yl-ethanol by reacting with piperidine.

General DescriptionColorless to dark brown liquid. Sweet burning taste.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
淮安铭赫新材料有限公司15952325815 15152323921 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
艾斯提克(山东)生物医药有限公司21-58999881 15623240527 · [email protected]

Related reactions

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