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Basic information
- CAS
20160-60-5- Standard SMILES
C[Si](C)(C)CCOC(=O)Cl- InChIKey
BTEQQLFQAPLTLI-UHFFFAOYSA-N- Molecular formula
- C6H13ClO2Si
- Average molar mass
- 180.707 g/mol
- Monoisotopic mass
- 180.03733387
Names & identifiers
- Preferred name
- 2-(TRIMETHYLSILYL)ETHYL CHLOROFORMATE
- IUPAC
- 2-(Trimethylsilyl)ethyl carbonochloridate
- English name
- (2-[(Chlorocarbonyl)oxy]ethyl)trimethylsilane
- Molecular formula
- C6H13ClO2Si
- Molecular weight
- 180.7
Names & synonyms
Teoc-Cl2-(Trimethylsilyl)ethyl carbonochloridate2-trimethylsilylethylchloroformate2-(trimethylsilyl)ethyl chloromethanoate(2-[(Chlorocarbonyl)oxy]ethyl)trimethylsilane2-(trimethylsilyl)chlorocarboxylic acid ethyl esterCarbonochloridic acid, 2-(trimethylsilyl)ethyl ester
Database identifiers
- CAS
20160-60-5- PubChem CID
- 10910168
- DTXSID
DTXSID90448018- EC Number
- 838-708-4
- Nikkaji
- J1.928.301A
Properties
Physicochemical properties
- Boiling point
- 42 · 42-43 °C(Press: 4 Torr)
- Density
- 0.9944 g/cm3 · 0.9944 g/cm3
- solubility
- 2 O; · Insol H2O; sol benzene, ether, THF, chloroform.
- Symbol(GHS)
- 2 · GHS02,GHS07,GHS05,GHS06
- Signal word
- Danger
- Hazard statements
- 314 · H314-H331-H226-H302
- Precautionary statements
- 264 · P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS07,GHS05,GHS06
- Hazard statements
- H314-H331-H226-H302
- Precautionary statements
- P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P311-P321-P403+P233-P405-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501
Chemistry & industry
Applications
Uses2-(Trimethylsilyl)ethyl Chloroformate is a reagent used in the introduction of the trimethylsilylethoxycarbonyl (Teoc) protecting group for amines or alcohols; activation of tertiary amines for dealkylation or ring opening; starting material for alternative reagents for introduction of the trimethylsilylethoxycarbonyl protecting group. It participates in the reactions of Protection of Amines, Protection of Alcohols, Dealkylation or Ring Opening of Tertiary Amines, Synthesis of Alternative Teoc Reagents etc.
Preparation methods
PreparationPrepared from 2-(trimethylsilyl)ethanol and phosgene.
Upstream & downstream products
Downstream products
Suppliers23 total
南京波普生物医药研发有限公司025-87138562 18951783565 · [email protected]
上海凌凯科技股份有限公司58950110 13124863828 · [email protected]
上海冬洋生物科技有限公司0512-13601744364 13601744364
砌块化学科技（上海）有限公司021-20432219 13918097649 · [email protected]
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
Related reactions
18 records
Compound notes
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