N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid

HCID 109334
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Basic information

CAS
68399-81-5
Standard SMILES
O=S(=O)(O)CC(O)CNC(CO)(CO)CO
InChIKey
RZQXOGQSPBYUKH-UHFFFAOYSA-N
Molecular formula
C7H17NO7S
Average molar mass
259.28 g/mol
Monoisotopic mass
259.07257288

Names & identifiers

Preferred name
N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acid
IUPAC
3-[[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]amino]-2-hydroxypropane-1-sulfonic acid
English name
TAPSO
Molecular formula
C7H17NO7S
Molecular weight
259.28

Names & synonyms

TAPSO68399-81-5N-[Tris(hydroxymethyl)methyl]-3-amino-2-hydroxypropanesulfonic acidEINECS 269-993-845Q4J0071UNSC 610929N-(Tris(hydroxymethyl)methyl)-3-amino-2-hydroxypropanesulfonic acidTAPSO [MI]NSC-6109291-Propanesulfonic acid, 2-hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)-DTXSID808873563-N-(2-Hydroxy-1,1-bis(hydroxymethyl)ethylamino)-2-hydroxypropanesulfonic acid
Show more names
APSOTAPSO BufferTAPSO FREE ACIDTAPSO ULTRAPURETAPSO,BIOLOGICALBUFFERTAPSO, for biochemistryTapso≥ 99.9% (titration)TAPSO ISO 9001：2015 REACHTAPSO FREE ACID SIGMAULTRA
2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)propanesulphonic acid1-Propanesulfonic acid, 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-2-Hydroxy-3-((2-hydroxy-1,1-bis(hydroxymethyl)ethyl)amino)-1-propanesulfonic acid3-(N-(TRIS(HYDROXYMETHYL)METHYL)AMINO)-2-HYDROXYPROPANESULFONIC ACID2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]propanesulphonic acidRefChem:8287432Hydroxy31propanesulfonic acidDTXCID80950135

Database identifiers

CAS
68399-81-5
PubChem CID
109334
DTXSID
DTXSID80887356
UNII
45Q4J0071U
EC Number
269-993-8
Nikkaji
J261.112K

Properties

Computed structural properties

XLogP
-6.4
Topological polar surface area
156 Ų
Hydrogen bond donors
6
Hydrogen bond acceptors
8
Rotatable bonds
8
Heavy atoms
16

Experimental & physicochemical properties

Chemical ClassesOther Uses -> Biological Buffers
Physical DescriptionColorless solid; [Merck Index] White crystalline solid; [Sigma-Aldrich MSDS]

Physicochemical properties

Melting point
224 · 224-229 °C (dec.)
Density
1.07607 g/cm3 · 1.07607 g/cm3(Temp: 25.00 °C)
storage temp.
Keep in dark place,Inert atmosphere,Room temperature
solubility
2 O: · H2O: 1 M at 20 °C, clear, colorless
form
Powder
color
Off-white to yellow

Safety & regulation

GHS classification

GHS Classification · 5 items

This chemical does not meet GHS hazard criteria for 4.5% (2 of 44) of reports.

Warning

H315 (95.5%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazards SummaryA skin and strong eye irritant; [Sigma-Aldrich MSDS] See 3-(Tris(hydroxymethyl)methylamino)-1-propanesulfonic acid.
Hazard Classes and CategoriesSkin Irrit. 2 (95.5%)

Safety data

PPE
dust mask type N95 (US), Eyeshields, Gloves
wgk
3
tsca
TSCA listed
hs_code
29221990
risk_code
36/37/38
Signal word
Warning

Chemistry & industry

Uses & manufacturing

UsesUsed as a biological buffer; [Merck Index]
General Manufacturing Information1-Propanesulfonic acid, 2-hydroxy-3-[[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino]-: ACTIVE
Applications · 1 item

UsesTAPSO is a zwitterionic biological buffer often used as a buffering agent in biological and biochemical research. It has a pKa value of 7.635 (I=0, 25°C) and can be used to make buffer solutions in the pH range 7.0-8.2. As an Good'buffer, TAPSO contains Tris groups and exhibits quite reactive activity with zwitterionic glycine peptides[1]. TAPSO can serve as good stabilizers for the globular protein BSA, in the aqueous solutions[2].The solubilities of TAPSO increase with increasing concentration of the salts (salting-in effect)[3].

Suppliers100 total

北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
湖北博杰生物科技有限公司0713-2060728 15629612610
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Related reactions

1 records
New reaction record

Compound notes

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