N,N,beta-Trimethyl-10H-phenothiazine-10-ethanamine
Basic information
- CAS
303-14-0- Standard SMILES
CC(CN(C)C)N1c2ccccc2Sc2ccccc21- InChIKey
CGNHCKZJGQDWBG-UHFFFAOYSA-N- Molecular formula
- C17H20N2S
- Average molar mass
- 284.4 g/mol
- Monoisotopic mass
- 284.13471982
Overview
Isopromethazine is a member of phenothiazines.
Names & identifiers
- Preferred name
- N,N,beta-Trimethyl-10H-phenothiazine-10-ethanamine
- IUPAC
- N,N-dimethyl-2-phenothiazin-10-ylpropan-1-amine
- English name
- Isopromethazine
- Molecular formula
- C17H20N2S
- Molecular weight
- 284.42
Names & synonyms
Isopromethazine303-14-0IsomethazineFen-BridalProthiazinN,N,beta-Trimethyl-10H-phenothiazine-10-ethanamine10-(2-Dimethylaminoisopropyl)phenothiazine044033O3TYLILLY-01526RP-4460RefChem:149784Isophenergan
Show more names
Promethazine hydrochloride impurity Bdimethyl(2-phenothiazin-10-ylpropyl)amineN,N,β-Trimethyl-10H-phenothiazine-10-ethanamine10H-Phenothiazine-10-ethanamine,N,N,b-trimethyl-N,N-dimethyl-2-phenothiazin-10-yl-propan-1-amine10-(2-Dimethylamino-1-methylethyl)-10H-phenothiazine
Promethazine EP Impurity BN,N-dimethyl-2-phenothiazin-10-ylpropan-1-aminedimethyl[2-(10H-phenothiazin-10-yl)propyl]amineN,N-dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amineLilly 01526UNII-044033O3TYRP 3389ISOPROMETHAZINE [MI]
Database identifiers
- CAS
303-14-0- PubChem CID
- 110669
- DTXSID
DTXSID10952662- ChEBI
Properties
Computed structural properties
- XLogP
- 4.2
- Topological polar surface area
- 31.8 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 3
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 298
Physicochemical properties
- Melting point
- 62 · 62-64 °C
- Boiling point
- 224 · 224-225 °C(Press: 11 Torr)
- Density
- 1.142 · 1.142±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- solubility
- Chloroform (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 8.948 · 8.948±0.28(predicted)
- color
- Pale Beige to Pale Brown
- FDA UNII
- 44033 O3TY · 044033O3TY
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents, usually topical, that relieve itching (pruritus).
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
Applications
UsesIsopromethazine is an impurity of Promethazine (P757000), an antihistamine used as an central nervous system depressant.
Additional notes
DefinitionChEBI: Isopromethazine is a member of phenothiazines.
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