Acesulfame Potassium

HCID 11074431CAS 55589-62-3

Basic information

Standard SMILES
CC1=CC(=O)[N-]S(=O)(=O)O1.[K+]
InChIKey
WBZFUFAFFUEMEI-UHFFFAOYSA-M
Molecular formula
C4H4KNO4S
Average molar mass
201.24 g/mol
Monoisotopic mass
200.94981029

Overview

Acesulfame k is a sulfuric acid derivative.

Names & identifiers

Preferred name
Acesulfame Potassium
IUPAC
potassium 6-methyl-2,2-dioxo-1-oxa-2λ6-thia-3-azanidacyclohex-5-en-4-one
English name
Acesulfame potassium
Molecular formula
C4H4KNO4S
Molecular weight
201.24

Names & synonyms

Acesulfame potassium55589-62-3Acesulfame KPotassium acesulfameOtizonPotassium acesulfamateAcesulfame potassium saltDTXSID1030606Sunett dAcesulfam-KINS-950E 950
Show more names
acesulfameACESULPHAMEPOTASSIUMACESULPHAME-KRARECHEM AM UC 0205AcesuLSWEET ONEAcesulfaml-KAcessulfame-KASPARTAMEACESULPHAMESALT
INS NO.950DTXCID9010606Hoe 095E-950NSC-7601041,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium saltRefChem:914951259-715-3

Database identifiers

CAS
55589-62-3
PubChem CID
11074431
DTXSID
DTXSID1030606
ChEMBL
CHEMBL1351474
ChEBI
CHEBI:184415
EC Number
259-715-3

Properties

Computed structural properties

Topological polar surface area
69.8 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
5
Rotatable bonds
0
Heavy atoms
11

Experimental & physicochemical properties

CosmeticsMasking; Oral care
Food AdditivesNON-NUTRITIVE SWEETENER -> FDA Substance added to food
SolubilityVery soluble in water, very slightly soluble in ethanol
Physical DescriptionOdourless, white, crystalline powder. Approximately 200 times as sweet as sucrose

Physicochemical properties

Melting point
229 · 229-232°C (dec.)
Boiling point
210 ℃[at · 210℃[at 101 325 Pa]
Density
1.81 g/cm3; · (solid) 1.81 g/cm3; d (bulk) 1.1-1.3 kg/dm3
vapor pressure
0.291 Pa · 0.291Pa at 25℃
storage temp.
Inert atmosphere,Room Temperature
solubility
Soluble in water, very slightly soluble in acetone and in ethanol (96 per cent).

Safety & regulation

GHS classification

GHS Classification · 3 items

This chemical does not meet GHS hazard criteria for 98.9% (174 of 176) of all reports.

Not Classified

Aggregated GHS information provided per 176 reports by companies from 4 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 5 items

Chemical: 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt

Regulation (EC) No 1333/2008 (amended)

1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Oxathiazin-4(3H)-one, 6-methyl-, 2,2-dioxide, potassium salt are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 26-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/10775

Potassium acesulfame: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesNot Classified

Safety data

wgk
1
rtecs
RP4489165
hs_code
2934990002
Toxicity
LD50 in rats (mg/kg): 7431 orally, 2243 i.p. (Mayer, Kemper)
risk_code
36/37/38
Signal word
Warning

Chemistry & industry

Uses & manufacturing

U.S. Production2023: 165 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesNot Known or Reasonably Ascertainable
Household ProductsInformation on 5 consumer products that contain Potassium acesulfame in the following categories is provided:
Use Classification · 4 items

Food additives

Food Additives -> FLAVOUR_ENHANCER; SWEETENER -> JECFA Functional Classes

Food Additives -> FLAVOUR_ENHANCER; SWEETENER -> JECFA Functional Classes

Cosmetics -> Masking; Oral care

General Manufacturing InformationNot Known or Reasonably Ascertainable
Applications · 5 items

DescriptionAcesulfame potassium is approved for use in food as a sweetener. It is included in the ingredient list on the food label as acesulfame K, acesulfame potassium, or Ace-K. Acesulfame potassium (Ace-K) is regulates as a food additive. The FDA approved acesulfame potassium for use in specific food and beverage categories in 1988 and in 2003 approved it as a general-purpose sweetener and flavor enhancer in food, except in meat and poultry, under certain conditions of use. It is widely used in the food industry, such as mouthwash and soft drinks. However, some researches have found that it does harm to the liver and nervous system[1-2].

HistoryAcesulfame-K, the potassium salt of acesulfame, is a sweetener that resembles saccharin in structure and taste profile. 5,6-Dimethyl-1,2,3-oxathiazine-4(3H)-one 2,2-dioxide, the first of many sweet compounds belonging to the dihydrooxathiazinone dioxide class, was discovered accidentally in 1967. From these many sweet compounds, acesulfame was chosen for commercialization. To improve water solubility, the potassium salt was made. Acesulfame-K (Sunett) was approved for dry product use in the United States in 1988 and in Canada in October, 1994. In 2003, acesulfame-K was approved as a general purposes sweetener by the FDA.

Uses'New generation', heat-stable sweetener that has not been suspected to cause cancer nor be genotoxic. Allelic variation of the Tas1r3 gene affects behavioral taste responses to this molecule, suggesting that it is a T1R3 receptor ligand.

UsesAcesulfame-K is the potassium salt of 6-methyl-l,2,3-oxathiazin-4(3H)- one-2,2-dioxide. This sweetener was discovered in Germany and was first approved by the FDA in 1988 for use as a nonnutritive sweetener. The complex chemical name of this substance led to the creation of the trademark common name, acesulfame-K, which is based on its following relationships to acetocetic acid and sulfanic acid, and to its potassium salt nature. Acesulfame-K is 200 times as sweet as sugar and is not metabolized and is thus noncaloric. It is exceptionally stable at elevated temperatures encountered in baking, and it is also stable in acidic products, such as carbonated soft drinks. It has a synergistic effect when mixed with other low-calorie sweetners, such as aspartame. Common applications of acesulfame-K are table uses, chewing gums, beverages, foods, bakery products, confectionary, oral hygiene products, and pharmaceuticals.

UsesPotassium salt as sweetener for foods, cosmetics.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Additional notes

DefinitionChEBI: Acesulfame k is a sulfuric acid derivative.

Related reactions

3 records

Linked notes

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