Basic information
- Standard SMILES
CC1CNCC(C)O1- InChIKey
HNVIQLPOGUDBSU-UHFFFAOYSA-N- Molecular formula
- C6H13NO
- Average molar mass
- 115.17 g/mol
- Monoisotopic mass
- 115.09971404
Overview
2,6-dimethyl morpholine is a clear liquid. (NTP, 1992)
Names & identifiers
- Preferred name
- 2,6-Dimethylmorpholine
- IUPAC
- 2,6-dimethylmorpholine
- English name
- Dimethylmorpholine
- Molecular formula
- C6H13NO
- Molecular weight
- 115.17
Names & synonyms
2,6-Dimethylmorpholine141-91-3Morpholine, 2,6-dimethyl-2,6-DIMETHYL MORPHOLINEDTXSID60220022,6-Dimethyl-2,3,5,6-tetrahydro-4H-1,4-oxazineDTXCID002002S5Z1B0318KNSC-60704RefChem:83327205-509-32,6-Dimethyl-Morpholine
Show more names
AKOS BBS-00004469Dimethylmorpholine2,6-dimethymorpholine*Dodemorph Impurity 92,6-dimethyl-morpholin2，6-Dimethyl morphalineMorpholine,2,6-dimethyl-
2,6-DimethylmorfolinMFCD000059732,6-Dimethylmorfolin [Czech]CCRIS 5910HSDB 4343EINECS 205-509-3NSC 60704BRN 0103036
Database identifiers
- CAS
141-91-3- PubChem CID
- 110862
- DTXSID
DTXSID6022002- EC Number
- 205-509-3
- Nikkaji
- J34.694B
Properties
Computed structural properties
- XLogP
- 0.3
- Topological polar surface area
- 21.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 66.9
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Morpholines
SpringerMaterials PropertiesChemical shift
PesticidesEnvironmental transformation -> Pesticide transformation products (metabolite, successor)
Density
0.9346 at 68 °F (NTP, 1992) - Less dense than water; will float
0.9346 @ 20 °C/20 °C
Color/FormLIQUID
Solubility
greater than or equal to 0.1 mg/mL at 66 °F (NTP, 1992)
SOL IN ALL PROPORTIONS WITH WATER, ALCOHOL, BENZENE, PETROLEUM ETHER; SOL IN ACETONE
Flash Point
112 °F (NTP, 1992)
112 °F (44 °C) OC
Boiling Point
297 °F at 760 mmHg (NTP, 1992)
146.6 °C @ 760 MM HG
Melting Point
-121 °F (NTP, 1992)
FREEZING POINT: -85 °C
Vapor Density4 (NTP, 1992) - Heavier than air; will sink (Relative to Air)
Refractive IndexINDEX OF REFRACTION: 1.4460 @ 20 °C/D
Physical Description
2,6-dimethyl morpholine is a clear liquid. (NTP, 1992)
Clear liquid; [CAMEO]
Physicochemical properties
- Melting point
- 85 °C · −85 °C(lit.)
- Boiling point
- 147 °C · 147 °C(lit.)
- Density
- 0.935 g/mL · 0.935 g/mL at 25 °C(lit.)
- refractive index
- 20 · n20/D 1.446(lit.)
- Flash point
- 120 °F · 120 °F
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Oil
- pka
- 9.04 · 9.04±0.60(Predicted)
- color
- Colourless
- Water Solubility
- 0.01 g/100 · >=0.01 g/100 mL at 19 ºC
- BRN
- 103036 · 103036
- Stability
- Stable. Incompatible with oxidizing agents, strong acids. Flammable.
- InChI
- 1S/C6H13NO/c1-5-3-7-4-6(2)8-5/h5-7H,3-4H2,1-2H3
- InChIKey
- HNVIQLPOGUDBSU-UHFFFAOYSA-N
- SMILES
- CC1CNCC(C)O1
- LogP
- -0.1 · -0.100 (est)
- CAS DataBase Reference
- 141 · 141-91-3(CAS DataBase Reference)
- FDA UNII
- 5 Z1B0318K · S5Z1B0318K
- NIST Chemistry Reference
- 2 · Morpholine, 2,6-dimethyl-(141-91-3)
- EPA Substance Registry System
- 2 · 2,6-Dimethylmorpholine (141-91-3)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 2 · GHS02,GHS05,GHS07
- Signal word
- Danger
- Hazard statements
- 226 · H226-H302-H312-H314
- Precautionary statements
- 210 · P210-P233-P240-P241-P242-P243-P280-P264-P270-P260-P303+P361+P353-P370+P378-P301+P312-P330-P302+P352-P312-P362+P364-P301+P330+P331-P363-P304+P340-P310-P305+P351+P338-P403+P235-P405-P501
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- Hazard Codes
- Xn
- Risk Statements
- 10 · 10-21-41
- Safety Statements
- 16 · 16-26-36/37/39-45
- RIDADR
- 1992 · UN 1992 3/PG 3
- WGK Germany
- 2 · 2
- RTECS
- 1750000 · QE1750000
- TSCA
- TSCA listed
- HazardClass
- 3 · 3
- PackingGroup
- III
- HS Code
- 29349990 · 29349990
- Storage Class
- 3 · 3 - Flammable liquids
- Hazard Classifications
- 4 DermalAcute · Acute Tox. 4 DermalAcute Tox. 4 OralFlam. Liq. 3Skin Corr. 1B
- Hazardous Substances Data
- 141 · 141-91-3(Hazardous Substances Data)
- REACH Registrations
- Active
- Limited Quantities
- 5 L · 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
Safety & regulation
GHS classification
GHS Classification
Danger
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
P210, P233, P240, P241, P242, P243, P260, P262, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P361+P364, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 213 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Morpholine, 2,6-dimethyl-
Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/16356
DOT LabelFlammable Liquid Poison
Fire HazardsThis chemical is combustible. (NTP, 1992)
Fire PotentialMODERATE FIRE RISK
Health HazardsSYMPTOMS: Symptoms of exposure to this chemical may include local irritation of the eyes and skin.
Hazards SummaryExternal application to rabbit eyes scored 7 on a scale of 1-10 (10 being most severe); Emergency treatment: Morpholine; [HSDB] A mild skin and severe eye irritant; [RTECS] See Morpholine.
Reactive GroupAmines, Phosphines, and Pyridines
Reactivity AlertsHighly Flammable
Reactivity Profile
2,6-DIMETHYL MORPHOLINE reacts with oxidizing agents (NTP, 1992). Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Air and Water ReactionsHighly flammable. Very slightly water soluble.
NFPA Hazard Classification
2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.
2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air.
0 - Materials that in themselves are normally stable, even under fire conditions.
Hazard Classes and CategoriesFlam. Liq. 3 (100%)
Safety & protection
Fire FightingFires involving this material should be controlled using a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Fire Fighting Procedures"ALCOHOL" FOAM
Nonfire Spill Response
SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
Isolation and EvacuationExcerpt from ERG Guide 131 [Flammable Liquids - Toxic]:
Personal Protective Equipment (PPE)
RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)
Toxicology
Non-Human Toxicity Excerpts2,6-DIMETHYLMORPHOLINE RATED 7 ON RABBIT EYES. MOST SEVERE INJURIES HAVE BEEN RATED 10.
Toxicity DataLC (rat) > 4,000 ppm/4h
Safety data
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- QE1750000
- ridadr
- UN 1992 3/PG 3
- hs_code
- 29349990
- risk_code
- 10-21-41
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS05,GHS07
- hazard_code
- Xn
- safety_code
- 16-26-36/37/39-45
- hazard_class
- 3
- Storage Class
- 3 - Flammable liquids
- packing_group
- III
- Hazard statements
- H226-H302-H312-H314
- Limited Quantities
- 5.0 L (1.3 gallons) (liquid)
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 OralFlam. Liq. 3Skin Corr. 1B
- Precautionary statements
- P210-P233-P240-P241-P242-P243-P280-P264-P270-P260-P303+P361+P353-P370+P378-P301+P312-P330-P302+P352-P312-P362+P364-P301+P330+P331-P363-P304+P340-P310-P305+P351+P338-P403+P235-P405-P501
- Hazardous Substances Data
- 141-91-3(Hazardous Substances Data)
Chemistry & industry
Uses & manufacturing
Uses
Used in corrosive inhibitors, stabilizers for chlorinated solvents, floor polishes, rubber additives, germicides, and textile finishing; [Hawley]
Using Disinfectants or Biocides [Category: Clean]
MFR OF CORROSION INHIBITORS; STABILIZER FOR CHLORINATED SOLVENTS; RUBLESS FLOOR POLISHES, RUBBER ACCELERATORS, GERMICIDES, TEXTILE FINISHING AGENTS, /PRC: FUNGICIDES/
Use ClassificationEnvironmental transformation -> Pesticide transformation products (metabolite, successor)
General Manufacturing InformationMorpholine, 2,6-dimethyl-: ACTIVE
Applications
Usescis-2,6-Dimethylmorpholine (DMMP) has been used in the preparation of microporous material composed of hybrid T2 and T3 supertetrahedral clusters.
General DescriptionClear liquid.
Upstream & downstream products
Downstream products
Related reactions
200 records
Linked notes
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