Basic information
- CAS
553-24-2- Standard SMILES
Cc1cc2nc3ccc(N(C)C)cc3nc2cc1N.Cl- InChIKey
PGSADBUBUOPOJS-UHFFFAOYSA-N- Molecular formula
- C15H16N4.ClH
- Average molar mass
- 288.77 g/mol
- Monoisotopic mass
- 288.11417422
Overview
Neutral red is a hydrochloride obtained by combining the free base of neutral red with one equivalent of hydrochloric acid. Neutral red acts as a pH indicator, changing from red to yellow between pH 6.8 and 8.0. It has a role as a dye, an acid-base indicator and a two-colour indicator. It contains a neutral red(1+).
Names & identifiers
- Preferred name
- Neutral Red
- IUPAC
- 8-N,8-N,3-trimethylphenazine-2,8-diamine;hydrochloride
- English name
- Neutral Red
- Molecular formula
- C15H16N4.ClH
- Molecular weight
- 288.78
Names & synonyms
NEUTRAL RED553-24-2Toluylene Red3-Amino-7-dimethylamino-2-methylphenazine hydrochlorideC.I. Basic Red 5Neutral Red chlorideMichrome No. 226Neutral Red W2,8-Phenazinediamine, N8,N8,3-trimethyl-, monohydrochlorideC.I. 50040Cerven neutralniCerven toluylenova
Show more names
Basic Red 5N2,N2,7-TriMethylphenazine-2,8-diaMine hydrochlorideKernechrotneutralredwc.i.basicred5michromeno.226cervenneutralnicervenzasadita5
C.I. Basic Red 5, monohydrochlorideCerven zasadita 5Aminodimethylaminotoluaminozine hydrochlorideNuclear Fast Red (basic dye)AI3-60242261QK3SSBHNSC-3092CHEBI:86370
Database identifiers
- CAS
553-24-2- PubChem CID
- 11105
- DTXSID
DTXSID90883440- ChEBI
Properties
Computed structural properties
- Topological polar surface area
- 55 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 1
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 319
Experimental & physicochemical properties
Chemical ClassesDyes -> Azine Dyes
Physical DescriptionDark green solid; [Merck Index]
Physicochemical properties
- Melting point
- 290 °C · 290 °C (dec.) (lit.)
- Boiling point
- 441.31 °C · 441.31°C (rough estimate)
- Density
- 1.159 · 1.1590 (rough estimate)
- bulk density
- 350 · 350-500kg/m3
- refractive index
- 1.611 · 1.6110 (estimate)
- storage temp.
- 5 °C · Store at +5°C to +30°C.
- solubility
- 2 O: · H2O: soluble10mg/mL
- Colour Index
- 50040 · 50040
- pka
- 6.7 · 6.7, 7.4(at 25℃)
- form
- Solid
- color
- Very dark green
- PH
- 3.1 · 3.1 (10g/l, H2O, 20℃)
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 11.1% (2 of 18) of reports.
Warning
H315 (77.8%): Causes skin irritation [Warning Skin corrosion/irritation]
P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 18 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: 2,8-Phenazinediamine, N8,N8,3-trimethyl-, monohydrochloride
Phenazine, 3-amino-7-(dimethylamino)-2-methyl-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryA skin, eye, and respiratory tract irritant; [MSDSonline]
Hazard Classes and CategoriesSkin Irrit. 2 (77.8%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- SG1400000
- hs_code
- 32041300
- Toxicity
- LD50 intraperitoneal in mouse: 432mg/kg
- risk_code
- 68-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn,Xi
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
Uses & manufacturing
UsesUsed as an indicator, biological stain, and drug; [ChemIDplus] Used to prepare neutral-red paper; [Merck Index] Azine dye; [Kirk-Othmer]
General Manufacturing Information2,8-Phenazinediamine, N8,N8,3-trimethyl-, hydrochloride (1:1): ACTIVE
Applications
DescriptionNeutral red is useful as a biological stain and as an indicator for preparing neutral red paper.
UsesCan be used as a vital stain, to stain living cells.
UsesNeutral Red is a common histology stain used to determine cell viability. It is also used as indicator for nitrogen determination; pH indicator; Dyes and metabolites.
General DescriptionNeutral red (C.I. 50040) is a protonated diaminophenazine dye. It is aminodimethylaminomethylphenazinehydrochloride, C15H17N4Cl.
Preparation methods
Related reactions
3 records
Compound notes
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