Chlorantraniliprole

In the event of fire, wear self-contained breathing apparatus. Use personal protective equipment. (on small fires) If area is heavily exposed to fire and if conditions permit, let fire burn itself out since water may increase the area contaminated. Cool containers / tanks with water spray. Control Runoff. /DuPont Dermacor X-100 Seed Treatment/

Suitable extinguishing media: Water spray, foam, dry chemical, carbon dioxide (CO2). /DuPont Dermacor X-100 Seed Treatment/

Do not subject to temperatures below 32 degrees F. Store product in original container only in a location inaccessible to children and pets. Do not contaminate water, other pesticides, fertilizer, food or feed in storage. Not for use or storage in or around the home. /DuPont Dermacor X-100 Seed Treatment/

Safe Storage of Pesticides. Always store pesticides in their original containers, complete with labels that list ingredients, directions for use, and first aid steps in case of accidental poisoning. Never store pesticides in cabinets with or near food, animal feed, or medical supplies. Do not store pesticides in places where flooding is possible or in places where they might spill or leak into wells, drains, ground water, or surface water. /Residential users/

Spill Cleanup: Soak up with sawdust, sand, oil dry or other absorbent material. Dispose of in an approved container. If liquid has been spilt in large quantities clean up promptly by scoop or vacuum. /DuPont Dermacor X-100 Seed Treatment/

If a spill occurs, clean it up promptly. Don't wash it away. Instead, sprinkle the spill with sawdust, vermiculite, or kitty litter. Sweep it into a plastic garbage bag, and dispose of it as directed on the pesticide product label./Residential users/

After Applying a Pesticide, Indoors or Outdoors. To remove pesticide residues, use a bucket to rinse tools or equipment three times, including any containers or utensils that you used when mixing the pesticide. Then pour the rinsewater into the pesticide sprayer and reuse the solution by applying it according to the pesticide product label directions. After applying any pesticide wash your hands and any other parts of your body that may have come in contact with the pesticide..To prevent tracking pesticides inside, remove or rinse your boots or shoes before entering your home. Wash any clothes that have been exposed to a lot of pesticide separately from your regular wash. /Residential users/

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal and plant life; and conformance with environmental and public health regulations.

Do not contaminate water, food or feed by storage or disposal. Wastes resulting from the use of this product must be disposed of on site or at an approved waste disposal facility. /DuPont Dermacor X-100 Seed Treatment/

Safe Disposal of Pesticides. The best way to dispose of small amounts of excess pesticides is to use them - apply them - according to the directions on the label. If you cannot use them, ask your neighbors whether they have a similar pest control problem and can use them. If all of the remaining pesticide cannot be properly used, check with your local solid waste management authority, environmental agency, or health department to find out whether your community has a household hazardous waste collection program or a similar program for getting rid of unwanted, leftover pesticides. These authorities can also inform you of any local requirements for pesticide waste disposal. /Residential users/

Safe Disposal of Pesticides. An empty pesticide container can be as hazardous as a full one because of residues left inside. Never reuse such a container. When empty, a pesticide container should be rinsed carefully three times and the rinsewater thoroughly drained back onto the sprayer or the container previously used to mix the pesticide. Use the rinsewater as a pesticide, following label directions. Replace the cap or closure securely. Dispose of the container according to label instructions. Do not puncture or burn a pressurized container like an aerosol - it could explode. Many communities have programs to recycle household waste such as empty bottles and cans. Do not recycle any pesticide containers, however, unless the recycling program specifically accepts pesticide containers and you follow the program's instructions for preparing the empty containers for collection. /Residential users/

... Must be used only in accordance with its labeling and with the Worker Protection Standard, 40 CFR Part 170. /DuPont Dermacor X-100 Seed Treatment/

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application. /DuPont Dermacor X-100 Seed Treatment/

Do not enter or allow worker entry into treated areas during the restricted-entry interval (REI) of 4 hours. Exception: If the seed is treated with the product and the treated seed is soil-injected or soil-incorporated, the Worker Protection Standard, under certain circumstances, allows workers to enter the treated area if there will be no contact with anything that has been treated. /DuPont Dermacor X-100 Seed Treatment/

/Restricted-entry interval (REI) of 4 hours./ For early entry into treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, wear: Long-sleeved shirt and long pants; Shoes plus socks. /DuPont Dermacor X-100 Seed Treatment/

For more Preventive Measures (Complete) data for Chlorantraniliprole (14 total), please visit the HSDB record page.

Tolerances are established for residues of the insecticide chlorantraniliprole, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only chlorantraniliprole, 3-bromo- N -[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide. [Table#7630]

Time-limited tolerances are established for the indirect or inadvertent residues of the insecticide chlorantraniliprole, including its metabolites and degradates, in or on the commodities in the table below when present therein as a result of the application of chlorantraniliprole to the growing crops listed in paragraph (a) of this section. Compliance with the tolerance levels specified below is to be determined by measuring only chlorantraniliprole, 3-bromo- N -[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide. [Table#7631]

Applicators and other handlers must wear: Long-sleeved shirt and long pants. Shoes plus socks. After the product has been diluted in accordance with label directions for use, shirt, pants, socks, and shoes are sufficient Personal Protective Equipment. /DuPont Dermacor X-100 Seed Treatment/

LD50; Species: Apis mellifera (Honey bee) oral >0.119 mg/bee /Chlorantraniliprole 35WG formulated product/ /from table/

LD50; Species: Apis mellifera (Honey bee) contact >0.100 mg/bee /Chlorantraniliprole 35WG formulated product/ /from table/

LD50; Species: Apis mellifera (Honey bee) oral >114.1 ug/bee /Chlorantraniliprole 20SC formulated product/ /from table/

LD50; Species: Colinus virginianus (Northern Bobwhite) oral >2250 mg/kg bw /Chlorantraniliprole technical/ /from table/

For more Ecotoxicity Values (Complete) data for Chlorantraniliprole (10 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 244 to 464(2), indicate that chlorantraniliprole is expected to have moderate mobility in soil(SRC). Volatilization of chlorantraniliprole from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.4X10-21 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Chlorantraniliprole is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-14 mm Hg at 25 °C(SRC), determined from a fragment constant method(4). Chlorantraniliprole has an environmental half-life of <2 to 12 months with shorter half-lives occurring with crop cover. This degradation is mostly abiotic(2).

AQUATIC FATE: Based on a classification scheme(1), Koc values of 244 to 464(2), indicate that chlorantraniliprole is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.4X10-21 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 31(SRC), from a log Kow of 2.76(2) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Chlorantraniliprole is stable to hydrolysis in the environment up to pH 9 at which point it has a half-life of 10 days(2). Biodegradation data in water were not available(SRC, 2010).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), chlorantraniliprole, which has an estimated vapor pressure of 1.2X10-14 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase chlorantraniliprole may be removed from the air by wet or dry deposition(SRC).

/AQUATIC SPECIES/ ... The acute toxicity of chlorantraniliprole to the red swamp crayfish Procambarus clarkii Girard was determined using aquatic and feeding assays. RESULTS: The aquatic 96 hr median lethal toxicity (LC50) data indicate that technical-grade chlorantraniliprole is highly toxic (US EPA category) to crayfish with an LC50 of 951 ug/L (95% CL = 741-1118 ug/L. A no observed effect concentration (NOEC) of 480 ug/L was recorded. Neither the 36 day chronic feeding study, where crayfish fed on chlorantraniliprole-treated rice seed in aquaria, nor the 144 hr acute feeding test, where crayfish fed on rice seeds treated with chlorantraniliprole, produced mortality or abnormal behavior. CONCLUSION: Chlorantraniliprole is three orders of magnitude less acutely toxic to P. clarkii than lambda-cyhalothrin and etofenprox, two pyrethroid insecticides also used in rice, and is less likely to cause acute crayfish toxicity in rice pond ecosystems. Based on acute toxicity data, the use of chlorantraniliprole should be more compatible with rice-crayfish crop rotations than pyrethroids.

/GENOTOXICITY/ In a cytogenetic assay, primary human lymphocyte cultures were exposed to DPX-E2Y45 Technical (chlorantraniliprole) at concentrations up to precipitating levels (> or = 750 ug/mL) and there were no statistically significant increases in the percentages of cells with structural aberrations or in polyploidy.

An estimated BCF of 31 was calculated in fish for chlorantraniliprole(SRC), using a log Kow of 2.76(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC).

The Henry's Law constant for chlorantraniliprole is estimated as 1.4X10-21 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that chlorantraniliprole is expected to be essentially nonvolatile from water surfaces(2). Chlorantraniliprole is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.2X10-14 mm Hg(SRC), determined from a fragment constant method(3).

/LABORATORY ANIMALS: Acute Exposure/ In a study of dermal sensitization using the Magnusson and Kligman maximization test, 20 Dunkin Hartley guinea-pigs were exposed to chlorantraniliprole technical (purity, 96.45%; solid powder). During the preliminary testing phase, the concentrations of the test substance used for the intradermal induction, topical induction and topical challenge, respectively, were 5% (w/w), 80% (w/w) and 20% (w/w), the highest non-irritating concentration. The vehicle was mineral oil. The control group consisted of 10 guinea-pigs. The first induction phase involved three paired intradermal injections of 0.1 mL of test substance, 0.1 mL of 50% (v/v) mixture of complete Freund adjuvant in distilled water and 0.1 mL of complete Freund adjuvant with test substance. The guinea-pigs in the control group were treated similarly with vehicle only. The topical induction phase was carried out 1 week later: the guinea-pigs were pre-treated with sodium lauryl sulfate 24 hr before topical applications of 0.5 g of chloroantraniliprole on a gauze pad for 48 hr under occlusion. In the challenge phase, 21 days after study initiation, the guinea-pigs received topical applications of 0.5 mL of the challenge dose and 0.5 ml of a 33% dilution of the challenge dose for 24 hr. At 24 hr and 48 hr after patch removal, the degree of dermal irritation was scored according to the Magnusson and Kligman grading scale. Data from appropriate historical controls exposed to alpha-hexylcinnamaldehyde technical (HCA) were used as the positive control. Statements of adherence to QA and GLP were included. After the intradermal and topical induction phases, very faint to moderate erythema (scores, 0.5-2) was noted at the treatment site in most guinea-pigs receiving chlorantraniliprole and in the control group. At challenge, very faint erythema (score, 0.5) was noted in some guinea-pigs receiving chlorantraniliprole at the highest non-irritating concentration and in some guinea-pigs in the control group. At treatment sites to which the 33% dilution was applied, no dermal reactions were noted.

/LABORATORY ANIMALS: Acute Exposure/ In a study of dermal sensitization groups of five female CBA/JHsd mice were given chlorantraniliprole technical (purity, 96.45%; solid powder) at a concentration of 0%, 5%, 25%, 50% or 100% (prepared at 1 g/mL in dimethylformanimide) w/v in the vehicle N,N-dimethylformanimide (DMF). The substance used as a positive control was 25% alpha-hexylcinnamaldehyde (HCA). For three consecutive days, the mice in each group were treated with 25 uL of the respective solutions on the dorsal surface of each ear. One group of mice was dosed similarly with the positive control, HCA in 4:1 acetone : olive oil (AAO), and one group of mice was dosed similarly with the vehicle used for the positive control only, AAO. On study day 5, the tail vein of each mouse was injected with 20 uCi of 3(H)methyl thymidine and the mice were killed 5 hr later. The single-cell suspensions of the auricular lymph nodes of each ear were incubated overnight and 3(H) activity was counted on day 6. A stimulation index was derived for each experimental group by comparison with the group receiving the vehicle control. A stimulation index of >/= 3 and/or a statistically significant increased stimulation index were considered to be a positive response. Statements of adherence to QA and GLP were included. No clinical signs of toxicity or statistically significant differences in body weights and bodyweight gains were observed. Stimulation indexes were approximately 1 at all concentrations tested. No statistically significant increases in cell proliferation were observed. The test system was validated by the dermal-sensitization response of the positive control, HCA. In this study, chloroantraniliprole was not a dermal sensitizer.

Chlorantraniliprole's production may result in its release to the environment through various waste streams; its use as an insecticide will result in its direct release to the environment. If released to air, an estimated vapor pressure of 1.2X10-14 mm Hg at 25 °C indicates chlorantraniliprole will exist solely in the particulate phase in the atmosphere. Particulate-phase chlorantraniliprole will be removed from the atmosphere by wet or dry deposition. If released to soil, chlorantraniliprole is expected to have moderate mobility based upon Koc values of 244 to 464. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 1.4X10-21 atm-cu m/mole. Chlorantraniliprole has an environmental half-life of <2 to 12 months with shorter half-lives occurring with crop cover. This degradation is mostly abiotic. If released into water, chlorantraniliprole is expected to adsorb to suspended solids and sediment based upon the Koc values. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 31 suggests the potential for bioconcentration in aquatic organisms is moderate. Chlorantraniliprole is stable to hydrolysis in the environment up to pH 9, at which point it has a half-life of 10 days. Occupational exposure to chlorantraniliprole may occur through inhalation and dermal contact with this compound at workplaces where chlorantraniliprole is produced or used. (SRC)

Tolerances are established for residues of the insecticide chlorantraniliprole, including its metabolites and degradates, in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only chlorantraniliprole, 3-bromo- N -[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide. [Table#7632]

Time-limited tolerances are established for the indirect or inadvertent residues of the insecticide chlorantraniliprole, including its metabolites and degradates, in or on the commodities in the table below when present therein as a result of the application of chlorantraniliprole to the growing crops listed in paragraph (a) of this section. Compliance with the tolerance levels specified below is to be determined by measuring only chlorantraniliprole, 3-bromo- N -[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide. [Table#7633]

For chlorantraniliprole (USEPA/OPP Pesticide Code: 090100) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Registered uses: pome fruit, stone fruit, leafy vegetables, cucurbit vegetables, fruiting vegetables, cotton, grapes, potatoes, rice, ornamentals, turf grass growing in resdential, commercial, and public landscaped areas

Insecticide

Composition: Technical is greater than or equal to 93%.

Flowable concentrate for seed treatment; granule; suspension concentrate (= flowable concentrate); water dispersible granule.

PREMIX PARTNERS: lambda-Cyhalothrin; Thiamethoxam.

Durivo (Syngenta Crop Protection, LLC.) 17.5% Thiamethoxam, 8.8% Chlorantraniliprole

For more Formulations/Preparations (Complete) data for Chlorantraniliprole (28 total), please visit the HSDB record page.

Insecticides

Environmental transformation -> Pesticides (parent, predecessor)