2-Methyl-6-nitroaniline

HCID 11298CAS 570-24-1

Basic information

Standard SMILES
Cc1cccc([N+](=O)[O-])c1N
InChIKey
FCMRHMPITHLLLA-UHFFFAOYSA-N
Molecular formula
C7H8N2O2
Average molar mass
152.15 g/mol
Monoisotopic mass
152.0585775

Overview

2-methyl-6-nitroaniline appears as orange-yellow prisms or brown granular powder. (NTP, 1992)

Names & identifiers

Preferred name
2-Methyl-6-nitroaniline
IUPAC
2-methyl-6-nitroaniline
English name
2-Methyl-6-nitroaniline
Molecular formula
C7H8N2O2
Molecular weight
152.15

Names & synonyms

2-METHYL-6-NITROANILINE570-24-12-Amino-3-nitrotoluene6-Nitro-o-toluidineBenzenamine, 2-methyl-6-nitro-6-Methyl-2-nitroaniline1-Amino-2-methyl-6-nitrobenzene3-Nitro-2-aminotolueneo-Toluidine, 6-nitro-2-nitro-6-methylanilineNSC 286OUP165YKBC
Show more names
2-Amino-3-nitro touleneNSC 52218-6-nitroaniL6-Nitro-o-tolLABOTEST-BB LTBB0006216-Nitro-2-Methylaniline
EINECS 209-329-62-Methyl-6-nitro-benzenamineIMEXINE FPNSC-286NSC-522182-amino-3-methylnitrobenzeneDTXSID7025631FCMRHMPITHLLLA-UHFFFAOYSA-

Database identifiers

CAS
570-24-1、60999-18-0
PubChem CID
11298
DTXSID
DTXSID7025631
UNII
OUP165YKBC
EC Number
209-329-6
Nikkaji
J28.416E

Properties

Computed structural properties

XLogP
2
Topological polar surface area
71.8 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
3
Rotatable bonds
0
Heavy atoms
11

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Nitroanilines
CosmeticsHair dyeing
SpringerMaterials PropertiesSurface tension
Density1.19 at 212 °F (NTP, 1992) - Denser than water; will sink
Solubilityless than 1 mg/mL at 73 °F (NTP, 1992)
Melting Point199 to 205 °F (NTP, 1992)

Physicochemical properties

Melting point
93 · 93-96 °C (lit.)
Boiling point
124 °C · 124 °C / 1mmHg
Density
1.19 g/cm3 · 1.19 g/cm3
refractive index
1.6276 · 1.6276 (estimate)
Flash point
110 °C · 110 °C
storage temp.
Keep in dark place,Inert atmosphere,Room temperature

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P260, P261, P262, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P316, P319, P321, P330, P361+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 47 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H311: Toxic in contact with skin [Danger Acute toxicity, dermal]

Hazard information

Regulatory Information · 3 items

Chemical: Benzenamine, 2-methyl-6-nitro-

Status: No longer Valid Update: 25-04-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24595

6-Nitro-o-toluidine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Benzenamine, 2-methyl-6-nitro-: Human health tier II assessment
DOT LabelPoison
Fire HazardsFlash point data for this compound are not available, but it is probably combustible. (NTP, 1992)
Health HazardsExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Hazards Summary · 1 item

A mild skin and eye irritant in rabbits at 3% concentration in 1,2-propanediol; No evidence of skin sensitization in guinea pigs; Hepatotoxicity observed in 28-day oral studies of rats; No evidence of embryotoxicity or teratogenicity in rats; [EC: SCCNFP] May cause irritation; May induce methemoglobinemia; Toxic by ingestion, inhalation, and skin absorption; Targets the blood; [Sigma-Aldrich MSDS] See 2-Nitroaniline.

Safety & protection

Fire FightingFires involving this material can be controlled using a carbon dioxide, dry chemical or Halon extinguisher. (NTP, 1992)
First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If a spill of this chemical occurs, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with acetone and transfer the dampened material to a suitable container. Use absorbent paper dampened with acetone to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with acetone followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Toxicology

Adverse EffectsOccupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

Safety data

F
10
PPE
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
wgk
3
ridadr
UN 2660 6.1/PG 3
hs_code
29214300
risk_code
23/24/25-33-51/53

Chemistry & industry

Uses & manufacturing

Uses · 2 items

Used in semi-permanent hair dyes; [EC: SCCNFP]

Dressing Hair [Category: Other]

Use ClassificationCosmetics -> Hair dyeing
Applications · 3 items

Uses2-Methyl-6-nitroaniline is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing.

Uses2-Methyl-6-nitroaniline (cas# 570-24-1) is a compound useful in organic synthesis. Dyes and metabolites, Environmental Testing

General DescriptionOrange-yellow prisms or brown granular powder.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
格林斯柏生物科技(江苏)有限公司0523-87726088 13705266400 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

Related reactions

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