Piconol
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Basic information
- CAS
586-98-1- Standard SMILES
OCc1ccccn1- InChIKey
SHNUBALDGXWUJI-UHFFFAOYSA-N- Molecular formula
- C6H7NO
- Average molar mass
- 109.13 g/mol
- Monoisotopic mass
- 109.05276384
Overview
2-Pyridinylmethanol is a member of pyridines.
Names & identifiers
- Preferred name
- Piconol
- IUPAC
- pyridin-2-ylmethanol
- English name
- 2-(Hydroxymethyl)pyridine
- Molecular formula
- C6H7NO
- Molecular weight
- 109.13
Names & synonyms
2-PYRIDINEMETHANOLpyridin-2-ylmethanolPiconol2-PyridylmethanolPyridine-2-methanol2-Pyridyl carbinolPiconol [INN]Piconolum [Latin]DTXSID8046531UNII-7HQ8UT1TPS7HQ8UT1TPSEINECS 209-592-7
Show more names
2-Pyridine(S)-Tryptophan Methyl ester hydrochloridePyridineMethanol2-PYRIDINYLMETHANOLPYRIDIN-2-YL-METHANOL2-Pyridine methanol(2-hydromethyl pyridine)
NSC-760363BRN 0107849DTXCID60265315-21-02-00150 (Beilstein Handbook Reference)Piconolum (Latin)NSC 7603632pyridylcarbinol2pyridylmethanol
Database identifiers
- CAS
586-98-1- PubChem CID
- 11474
- DTXSID
DTXSID8046531- ChEMBL
CHEMBL2103981- ChEBI
CHEBI:195070- UNII
- 7HQ8UT1TPS
- EC Number
- 209-592-7
- Nikkaji
- J32.889H
Properties
Computed structural propertiesFilling in
- XLogP
- 0.1
- Topological polar surface area
- 33.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 1
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 65.5
Experimental & physicochemical properties
Chemical ClassesNitrogen Compounds -> Pyridines
SpringerMaterials PropertiesSurface tension
LogP0.06
Vapor Pressure0.02 [mmHg]
Physical DescriptionClear hygroscopic liquid; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 5 °C · 5 °C
- Boiling point
- 112 · 112-113 °C/16 mmHg (lit.)
- Density
- 1.131 g/mL · 1.131 g/mL at 25 °C (lit.)
- vapor pressure
- 3.47 Pa · 3.47Pa at 25℃
- refractive index
- 20 · n20/D 1.543(lit.)
- Flash point
- 230 °F · >230 °F
- storage temp.
- 2 · 2-8°C
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (87.7%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 57 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Status: Active Update: 12-09-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/19922
2-Pyridylmethanol: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryIntravenous LD50 (mouse) = 1,000 mg/kg; [RTECS] A skin and strong eye irritant; Harmful by ingestion; [Sigma-Aldrich MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (87.7%)
Safety data
- F
- 3-8
- PPE
- Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
- wgk
- 3
- rtecs
- UT4689000
- hs_code
- 29333999
- risk_code
- 36/37/38-22
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi,Xn
Chemistry & industry
Applications
Usesdecongestant
UsesA pyridylalcohol with hypoglycemic activity and potential apoptotic effect in human leukemia cells.
Uses2-Pyridinemethanol is used as a pyridylalcohol with hypoglycemic activity.
Preparation methods
PreparationThe preparation of 2-(Hydroxymethyl)pyridine is as follows:NaOH (0.5 g, 12.5 mmol), Al2O3 (2.0 g, 19.6 mmol), aldehyde 1f-g (2 mmol) and H2O (400 μL) were grinded in a mortar. Next, the paste were placed in a glass 10 mL pressure vials and reaction was carried out in microwave reactor: standard mode (200 W), 100 °C, 2 min. After that, reaction mixture was extracted with DCM (2 × 20 mL). Organic layer was evaporated under reduce pressure yielding 2f-g. Solid residue was washed by water (2 × 15 mL). Aqueous phase was acidify with 1N HCl to pH 5.5 and centrifuged. After that aqueous layer was pour down and precipitate was lyophilisated. Products 3f-g were obtained as white solids.
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
251 records
Compound notes
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