CAS 556-03-6 DL-Tyrosine (HCID 1153)

Names & identifiers

Preferred name: DL-Tyrosine
IUPAC: 2-amino-3-(4-hydroxyphenyl)propanoic acid
English name: DL-Tyrosine
Molecular formula: C9H11NO3
Molecular weight: 181.19

Names & synonyms

DL-Tyrosine556-03-6Tyrosine, DL-A9BAT9B32MNSC 205006EINECS 209-113-1NSC-205006AI3-18479DTXSID50859040NSC205006RefChem:589985DTXCID00199786

Show more names

DL-TyrDL-Tyr-OHDL-TyrosinDL-TyrozineDL-Tyrosine 0DL-p-Tyrosine

2-azaniumyl-3-(4-hydroxyphenyl)propanoate209-113-1H-DL-Tyr-OH2-amino-3-(4-hydroxyphenyl)propanoic acid(.+-.)-TyrosineMFCD00063074DL-TYROSINE-BETA-13CDL-4-Hydroxyphenylalanine-15N

Database identifiers

CAS: 556-03-6、60-18-4
PubChem CID: 1153
DTXSID: DTXSID50859040
ChEMBL: CHEMBL108615
ChEBI: CHEBI:18186
UNII: A9BAT9B32M
EC Number: 209-113-1
Nikkaji: J598.196D

Properties

Computed structural properties

XLogP: -2.3
Topological polar surface area: 83.6 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 4
Rotatable bonds: 3
Heavy atoms: 13
Formal charge: 0
Complexity: 176

Physicochemical properties

Melting point: 300 °C · ≥300 °C (lit.)
Boiling point: 314.29 °C · 314.29°C (rough estimate)
Density: 1.2375 · 1.2375 (rough estimate)
refractive index: 1.527 · 1.5270 (estimate)
storage temp.: Store at RT.
solubility: Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly)
pka: 1 · pK1:2.18(+1);pK2:9.11(0);pK3:10.6(OH) (25°C)
form: Crystalline
color: White to Off-White
Water Solubility: Soluble in water.
ex/em: 275 nm; · λex 275 nm; λem 303 nm in H2O, PO4 buffer
Merck: 14 · 14,9839
BRN: 515881 · 515881
Stability: Stable. Incompatible with strong oxidizing agents.
Major Application: peptide synthesis
Cosmetics Ingredients Functions: SKIN CONDITIONINGFRAGRANCEANTISTATICHAIR CONDITIONING
InChI: 1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)
InChIKey: OUYCCCASQSFEME-UHFFFAOYSA-N
SMILES: NC(Cc1ccc(O)cc1)C(O)=O
LogP: -0.418 · -0.418 (est)
CAS DataBase Reference: 556 · 556-03-6(CAS DataBase Reference)
FDA UNII: 9 BAT9B32M · A9BAT9B32M
NIST Chemistry Reference: 2 · 2-Amino-3-(4-hydroxyphenyl)-propanoic acid(556-03-6)
EPA Substance Registry System: Tyrosine (556-03-6)
UNSPSC Code: 12352209 · 12352209
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 315 · H315-H319-H335
Precautionary statements: 261 · P261-P280a-P304+P340-P305+P351+P338-P405-P501a
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 36 · 36/37/38
Safety Statements: 26 · 26-36
WGK Germany: 3 · 3
TSCA: TSCA listed
HS Code: 29225000 · 29225000
Storage Class: 11 · 11 - Combustible Solids

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 82% (41 of 50) of all reports.

Warning

H315 (18%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (18%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (16%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 50 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 41 of 50 reports by companies.；There are 6 notifications provided by 9 of 50 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory InformationChemical: DL-Tyrosine

Other Safety InformationIMAP assessments - DL-Tyrosine: Environment tier I assessment；Evaluation - Chemicals that are unlikely to require further regulation to manage risks to human health

Hazard Classes and CategoriesSkin Irrit. 2 (18%)；Eye Irrit. 2 (18%)；STOT SE 3 (16%)

Regulatory information

Regulatory InformationChemical: DL-Tyrosine

Safety data

PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
hs_code: 29225000
risk_code: 36/37/38
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xi
safety_code: 26-36
Storage Class: 11 - Combustible Solids
Hazard statements: H315-H319-H335
Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Chemistry & industry

Uses & manufacturing

UsesUse (kg; approx.) in Germany (2009): >750；Consumption (g per capita; approx.) in Germany (2009): 0.00916；Calculated removal (%): 75.1

General Manufacturing InformationTyrosine: ACTIVE

Applications · 1 item

UsesThe tyrosine of this diet was labeled by adding to it an amount of synthetic, isotopic dl-tyrosine cor- responding to twice that already present in the food. Incorporation of total C14 into muscle protein was reduced in 186-day infected mice fed dl-tyrosine-2-C-14 as compared to muscle proteins obtained from noninfected animals.

Upstream & downstream products

Upstream raw materials

Downstream products

D-Tyrosine

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

T&W GROUP021-61551611 13296011611 · [email protected]

Additional notes · 1 item

DefinitionChEBI: Tyrosine is an alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring. It has a role as a Daphnia magna metabolite. It is an alpha-amino acid, a polar amino acid and an aromatic amino acid. It contains a 4-hydroxybenzyl group. It is functionally related to a propionic acid. It is a conjugate base of a tyrosinium. It is a conjugate acid of a tyrosinate(1-).