Basic information
- CAS
888478-45-3- Standard SMILES
COc1cc(OC)cc(N2CCN(C(=O)Nc3nc4cc(F)ccc4nc3OC)CC2)c1- InChIKey
KAKPGJJRYRYSTP-UHFFFAOYSA-N- Molecular formula
- C22H24FN5O4
- Average molar mass
- 441.5 g/mol
- Monoisotopic mass
- 441.18123243
Overview
Supinoxin is under investigation in clinical trial NCT02003092 (RX-5902 Treatment of Subjects With Triple Negative Breast Cancer).
Names & identifiers
- Preferred name
- Supinoxin
- IUPAC
- 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamide
- English name
- Supinoxin
- Molecular formula
- C22H24FN5O4
- Molecular weight
- 441.46
Names & synonyms
Supinoxin888478-45-3RX-5902P-P68 inhibitor RX-5902ZU8OM8V5WF4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-quinoxalin-2-yl)piperazine-1-carboxamide1-Piperazinecarboxamide, 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-1-(3,5-Dimethoxyphenyl)-4-((6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl) piperazineRefChem:1804054-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxyquinoxalin-2-yl)piperazine-1-carboxamideUNII-ZU8OM8V5WFSCHEMBL1137972
Show more names
Supinoxin (RX-5902)Supinoxin, 10 mM in DMSO1-(3,5-dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl]piperazinebreast,inhibit,PANC-1,Inhibitor,Supinoxin,HCT116,UMRC2,PC-3,MKN-45,TNBC,HepG2,DNA/RNA Synthesis,RNA helicase,HT29,cancer,Apoptosis,A549,Caki-1,RX5902,RX 5902
SB19791HY-123611Supinoxin?orb1307712CHEMBL1278118SCHEMBL29422967RX-5902 (SUPINOXIN)GLXC-15740
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 89.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 5
- Heavy atoms
- 32
- Formal charge
- 0
- Complexity
- 611
Physicochemical properties
- solubility
- 25 mg/mlDMSO: · DMF: 25 mg/mlDMSO: 10 mg/ml
- form
- Solid
- color
- White to off-white
- FDA UNII
- 8 OM8V5WF · ZU8OM8V5WF
- NCI Drug Dictionary
- supinoxin
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319
- Precautionary statements
- 501 · P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319
- Precautionary statements
- P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330
Chemistry & industry
Applications
UsesSupinoxin (RX-5902) is an orally active inhibitor of phosphorylated-p68 RNA helicase (P-p68) and a potent first-in-class anti-cancer agent. Supinoxin interacts with Y593 phosphorylated-p68 and attenuates the nuclear shuttling of β-catenin. Supinoxin induces cell apoptosis and inhibits growth of TNBC cancer cell lines with IC50s ranging from 10 nM to 20 nM[1][2].
Suppliers14 total
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
上海瀚香生物科技有限公司177-54423994 17754423994 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
HANGZHOU LEAP CHEM CO., LTD.+86-571-87711850 +86-15355479329 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海志信生物医药科技有限公司18701958033 · [email protected]
上海宏叶生物科技有限公司
Related reactions
3 records
Compound notes
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