Ripasudil Hydrochloride
Basic information
- CAS
887375-67-9- Standard SMILES
C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(F)c12.Cl.O.O- InChIKey
CMDJNMACGABCKQ-XVSRHIFFSA-N- Molecular formula
- C15H23ClFN3O4S
- Average molar mass
- 395.9 g/mol
- Monoisotopic mass
- 395.1081833
Names & identifiers
- Preferred name
- Ripasudil Hydrochloride
- IUPAC
- 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline;dihydrate;hydrochloride
- English name
- Ripasudil hydrochloride dihydrate
- Molecular formula
- C15H21ClFN3O3S
- Molecular weight
- 377.86
Names & synonyms
887375-67-9Ripasudil hydrochloride dihydrateK-115glanatecRipasudil hydrochloride hydrateripasudil hydrochloride016TTR32QFK-115-R1H-1,4-Diazepine, 1-((4-fluoro-5-isoquinolinyl)sulfonyl)hexahydro-2-methyl-, monohydrochloride, dihydrate, (2S)-K-321Isoquinoline, 4-fluoro-5-(((2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl)sulfonyl)-, hydrochloride, hydrate (1:1:2)1H-1,4-Diazepine, 1-[(4-fluoro-5-isoquinolinyl)sulfonyl]hexahydro-2-methyl-, monohydrochloride, dihydrate, (2S)-
Show more names
K-115 HCLK 115K115 HCL 2H2OK-115 (HCl H2O)Ripasudil (K-115)K115 HCl DihydrateRipasudil free baseK 155 HCl dihydrateRipasudilHCl Hydrate
Isoquinoline, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-, hydrochloride, hydrate (1:1:2)K115 compoundRefChem:179485Ripasudil HCl dihydrateK115Ripasudil (K-115) hydrochloride dihydrate(S)-4-Fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline hydrochloride dihydrateRipasudil(K-115)
Database identifiers
- CAS
887375-67-9- PubChem CID
- 11625386
- DTXSID
DTXSID401366231- ChEMBL
CHEMBL4594454- UNII
- 016TTR32QF
Properties
Computed structural properties
- Topological polar surface area
- 72.7 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 8
- Rotatable bonds
- 2
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 482
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 123.2 mg/mL · insoluble in EtOH; ≥123.2 mg/mL in DMSO; ≥41.7 mg/mL in H2O
- form
- solid
- color
- White to off-white
- Stability
- Hygroscopic
- FDA UNII
- 16 TTR32QF · 016TTR32QF
- Risk Statements
- 24 · 24/25-26-28
- Safety Statements
- 28 · 28-38-41-48
- HS Code
- 29339900 · 29339900
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- hs_code
- 29339900
- risk_code
- 24/25-26-28
- safety_code
- 28-38-41-48
Chemistry & industry
Applications
DescriptionRipasudil hydrochloride hydrate (Glanatec®) was approved in Japan in 2014 for the treatment of glaucoma and ocular hypertension. Originally discovered by D. Western Therapeutics Institute, Inc. and licensed by the Kowa Company, Ltd, ripasudil functions as a selective Rho-kinase inhibitor and reduces intraocular pressure by stimulation of aqueous humour drainage of the trabecular meshwork. While this recent approval allows for use of ripasudil as a twice-daily monotherapy treatment when other drugs cannot be used or are not effective, clinical trials using ripasudil as a combination therapy with other glaucoma drugs have shown promising results in the treatment of primary open-angle glaucoma or ocular hypertension. Currently, the Kowa Company is also pursuing trials focused on the use of ripasudil for the treatment of diabetic retinopathy and diabetic macular edema.
UsesRipasudil Hydrochloride Dihydrate is a derivative of fasudil and a rho kinase inhibitor (1,2). It is used for the treatment of glaucoma and ocular hypertension.
UsesRipasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…