Basic information
- CAS
900515-16-4- Standard SMILES
O=C1NC(=O)/C(=C/c2ccc(-c3ccc(F)cc3O)o2)S1- InChIKey
OYYVWNDMOQPMGE-SDQBBNPISA-N- Molecular formula
- C14H8FNO4S
- Average molar mass
- 305.28 g/mol
- Monoisotopic mass
- 305.01580707
Names & identifiers
- Preferred name
- AS-252424
- IUPAC
- (5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
- English name
- 5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
- Molecular formula
- C14H8FNO4S
- Molecular weight
- 305.28
Names & synonyms
AS-252424900515-16-4AS252424AS 25242463D4RUV1GN2,4-Thiazolidinedione, 5-((5-(4-fluoro-2-hydroxyphenyl)-2-furanyl)methylene)-, (5Z)-(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione(5Z)-5-{[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione(5Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylidene)-1,3-thiazolidine-2,4-dioneRefChem:114422(Z)-5-((5-(4-fluoro-2-hydroxyphenyl)furan-2-yl)methylene)thiazolidine-2,4-dioneUNII-63D4RUV1GN
Show more names
CS-182S-252424AS-252424casAS-252424 ，S2671AS-252424, 10 mM in DMSOAS-252424, PI3Kgamma inhibitor5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CHEMBL379156SCHEMBL1494573HMS3229L07HMS3650K14NCGC00185997-01SR-02000000888-2(5Z)-5-[[5-(4-Fluoro-2-hydroxyphenyl)-2-furanyl]methylene]-2,4-thiazolidinedione1138220-19-5
Properties
Computed structural properties
- XLogP
- 2.7
- Topological polar surface area
- 105 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 2
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 484
Physicochemical properties
- Melting point
- 235 oC · >235oC (dec.)
- Density
- 1.559 · 1.559±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- 20 mg/mL · DMSO: >20mg/mL
- pka
- 7.2 · 7.20±0.20(Predicted)
- form
- solid
- color
- yellow
- FDA UNII
- 63 D4RUV1GN · 63D4RUV1GN
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319
- Precautionary statements
- 305 · P305+P351+P338
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319
- Precautionary statements
- P305+P351+P338
Chemistry & industry
Applications
UsesAS-252424 is a novel, potent, and selective phosphoinositide 3-kinase gamma (PI3Kγ) inhibitor. It is also an inhibitor of Casein kinase and PI3K p110α.
Suppliers88 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
武汉布林科技有限公司3456065315 13260619011 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
武汉众志诚生物技术有限公司13628624121 13628604890 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
北京华威锐科化工有限公司0757-86329057 18934348241 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…