Pulchinenoside B4
Anemoside B4 · Pulchinenoside C · Anemoside B4 Pulchinenoside B4 · Chinensioside A · PULCHINENOSIDE B4 · Pulsatilla saponin B4 · Pulchinenoside B4 CRS · AnemosideB4 129741-57-7
Identifiers & Physical Properties
| CAS No. | 129741-57-7 |
|---|---|
| Molecular formula | C59H96O26 |
| Average molar mass | 1,221.4 g/mol |
| Monoisotopic mass | 1,220.61898316 g/mol |
| SMILES | C=C(C)[C@@H]1CC[C@]2(C(=O)O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@@H]12 |
| InChIKey | OUHBKBTZUPLIIA-OTEDBJMHSA-N |
| PubChem CID | 11636713 |
| ChEMBL | CHEMBL450226 |
Chemical & Physical Properties
| XLogP | -1.2 |
|---|---|
| Topological polar surface area | 413 |
| Hydrogen bond donors | 15 |
| Hydrogen bond acceptors | 26 |
| Rotatable bonds | 15 |
| Heavy atoms | 85 |
| Formal charge | 0 |
| Complexity | 2,340 |
| Melting point | 208-215℃ |
| Density | 1.48 |
| Solubility | DMSO : 125 mg/mL (102.34 mMNeed ultrasonic) |
| Physical state | Powder |
| pKa (acidity coefficient) | 12.50±0.70(Predicted) |
| Color | White to light yellow |
| Major applications | pharmaceutical |
| InChIKey | OUHBKBTZUPLIIA-UFEMLMIJNA-N |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
Applications & Uses
Description
Pulchinenoside B4 is a triterpenoid glycoside that has been found in P. chinensis and has diverse biological activities. It inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities in HEK293 cells when used at concentrations of 6 and 12 μM. Pulchinenoside B4 (50 and 100 mg/kg twice per day) prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels, markers of kidney injury, in a mouse model of cisplatin-induced nephrotoxicity. It prevents xylene-induced ear edema in mice in a dose-dependent manner. Pulchinenoside B4 (50 mg/kg) inhibits LPS-induced increases in serum TNF-α, IL-6, and IL-1β levels a mouse model of LPS-induced systemic inflammation.
Uses
Pulchinenoside C is a triterpenoid saponin extract which acts as a minor molluscicidal agent in addition to tumor necrosis factor-α secretion inhibition. Anti-inflammatory.