Basic information
- CAS
359010-70-1- Standard SMILES
Nc1ccc(Oc2ccc3c(-c4ccccc4C(=O)O)c4ccc(=O)cc-4oc3c2)cc1- InChIKey
GIERQYKZWFLVGR-UHFFFAOYSA-N- Molecular formula
- C26H17NO5
- Average molar mass
- 423.4 g/mol
- Monoisotopic mass
- 423.11067264
Names & identifiers
- Preferred name
- 2-[6-(4-Aminophenoxy)-3-oxo-3H-xanthen-9-yl]benzoic acid
- IUPAC
- 2-[3-(4-aminophenoxy)-6-oxoxanthen-9-yl]benzoic acid
- English name
- APF
- Molecular formula
- C26H17NO5
- Molecular weight
- 423.42
Names & synonyms
2-(6-(4-Aminophenoxy)-3-oxo-3H-xanthen-9-yl)benzoic acidDTXSID404698792-[6-(4-AMINOPHENOXY)-3-OXO-3H-XANTHEN-9-YL]BENZOIC ACIDRefChem:252973DTXCID90420697962-224-32-[3-(4-aminophenoxy)-6-oxoxanthen-9-yl]benzoic acid2-[6-(4-Aminophenoxy)-3-oxo-3H-xanthen-9-yl]-benzoic acid686773-85-3H377282-(6-(4-Aminophenoxy)-3-oxo-3H-xanthen-9-yl)benzoicacidAPF
Show more names
AMINOPHENYL FLUORESCEIN3-(p-Aminophenyl)fluorescein3-(p-Aminophenyl)fluorescein , APF2-[6-(4'-AMINO)PHENOXY-3H-XANTHEN-3-ON-9-YL]BENZOIC ACID3'-(4-aminophenoxy)-6'-hydroxyspiro[2-benzofuran-3,9'-xanthene]-1-oneSpiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 3'-(4-aminophenoxy)-6'-hydroxy-
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 3.6
- Topological polar surface area
- 98.9 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 4
- Heavy atoms
- 32
- Formal charge
- 0
- Complexity
- 850
Experimental & physicochemical properties
Endocrine DisruptorsPotential endocrine disrupting compound
Physicochemical properties
- Boiling point
- 677.7 · 677.7±55.0 °C(Predicted)
- Density
- 1.52 · 1.52±0.1 g/cm3(Predicted)
- storage temp.
- -20 °C · Store at -20°C
- solubility
- 20 · DMF:20.0(Max Conc. mg/mL);47.23(Max Conc. mM)DMSO:10.0(Max Conc. mg/mL);23.62(Max Conc. mM)Ethanol:10.0(Max Conc. mg/mL);23.62(Max Conc. mM)Ethanol:PBS (pH 7.2) (1:3):0.5(Max Conc. mg/mL);1.18(Max Conc. mM)
- form
- Pale yellow liquid.
- pka
- 9.61 · 9.61±0.20(Predicted)
- color
- Colorless to light yellow
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319
- Precautionary statements
- 501 · P501-P270-P264-P280-P337+P313-P301+P312+P330
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319
- Precautionary statements
- P501-P270-P264-P280-P337+P313-P301+P312+P330
Chemistry & industry
Applications
DescriptionAPF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals. APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxima of 490/515 nm, respectively.
UsesAPF is a fluorescence probe that can selectively, and dose dependently detect certain species among ROS and that are highly resistant to autoxidation. APF can be used in enzymatic and cellular systems[1].
Suppliers29 total
武汉敬康恩生物医药科技有限公司13720134139 086-15871494362 13720134139 · [email protected]
武汉布林科技有限公司3456065315 13260619011 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
江苏星科元信息科技有限公司400-605-7200 15335295587 · [email protected]
浙江珲达生物科技有限公司0571-89903022 18679456698 · [email protected]
西安凯新生物科技有限公司029-68881181 13619217766 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…