1-Chloro-2,6-dinitrobenzene

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Employees should wash immediately when skin becomes wet, and promptly when skin becomes contaminated; Work clothing should be changed daily if it is reasonably probable that the clothing is contaminated; Remove clothing: immediately remove any non-impervious clothing that becomes wet, and promptly remove any non-impervious clothing that becomes contaminated. /Dinitrobenzene/

The following equipment should be available: quick drench. /Dinitrobenzene/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Wear appropriate equipment to prevent reasonable probability of skin contact; wear eye protection to prevent reasonable probability of eye contact. /Dinitrobenzene/

Respirator selection: Upper limit devices recommended by OSHA: 5 mg/cu m: any dust and mist respirator except single-use respirators; 10 mg/cu m: any dust and mist respirator except single-use and quarter-mask respirators or any supplied air respirator or high-efficiency particulate filter or any self-contained breathing apparatus; 25 mg/cu m: any powdered air-purifying respirator with a dust and mist filter or any supplied-air respirator operated in a continuous flow mode; 50 mg/cu m: high-efficiency particulate filter or any powered air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter or any self-contained breathing apparatus with a full facepiece or any supplied-air respirator with a full facepiece or any supplied-air respirator with a tight-fitting facepiece operated in a continuous flow mode; 200 mg/cu m: any supplied-air respirator with a half-mask and operated in a pressure-demand or other positive pressure mode; Emergency or planned entry in unknown concn or IDLH conditions: any self-contained breathing apparatus with a full facepiece and operated in a pressure-demand or other positive pressure mode or any supplied-air respirator with a full facepiece and operated in a pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode; escape: any air-purifying full facepiece respirator with a high-efficiency particulate filter or any appropriate escape-type self-contained breathing apparatus. /Dinitrobenzene/

... CHRONIC POISONING BY INDUSTRIAL EXPOSURE ... CAUSE GRADUAL ONSET OF SYMPTOMS OF RETROBULBAR NEURITIS, WITH BLURRING OF VISION, CENTRAL SCOTOMA, ESPECIALLY FOR GREEN, & CONSTRICTION OF VISUAL FIELDS. @ FIRST OPHTHALMOSCOPIC FINDINGS ARE NORMAL, BUT OPTIC NEURITIS MAY GRADUALLY BECOME EVIDENT ... . /DINITROCHLOROBENZENE/

CHRONIC POISONING BY INDUSTRIAL EXPOSURE ... IMPAIRED PUPILLARY REACTION IN ACCOMMODATION HAS BEEN NOTED DESPITE GOOD PUPILLARY RESPONSE TO LIGHT. TYPICALLY THE RETROBULBAR NEURITIS HAS BEEN ASSOCIATED WITH PERIPHERAL NEURITIS MANIFEST AS PARESTHESIAS & PAINS IN LEGS & BURNING OF FEET. /DINITROCHLOROBENZENE/

Mutagenicity of 102 aliphatic and aromatic nitro compounds, industrial materials and related chemicals were tested by pre-incubation method using Salmonella typhimurium TA100 and TA98 strains with and without S9 mix. ... Mutagenicity of dinitrobenzene was enhanced by the introduction of ... chloro- group. ... /Chlorodinitrobenzenes/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Aniline and related compounds/