Basic information
- CAS
32857-62-8- Standard SMILES
O=C(O)Cc1ccc(C(F)(F)F)cc1- InChIKey
HNORVZDAANCHAY-UHFFFAOYSA-N- Molecular formula
- C9H7F3O2
- Average molar mass
- 204.15 g/mol
- Monoisotopic mass
- 204.03981412
Names & identifiers
- Preferred name
- (alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid
- IUPAC
- 2-[4-(trifluoromethyl)phenyl]acetic acid
- English name
- 4-(Trifluoromethyl)phenylacetic acid
- Molecular formula
- C9H7F3O2
- Molecular weight
- 204.15
Names & synonyms
32857-62-8Benzeneacetic acid, 4-(trifluoromethyl)-4-(TRIFLUOROMETHYL)BENZENEACETIC ACID(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidEINECS 251-263-5DTXSID40186514RefChem:405672DTXCID80109005251-263-54-(Trifluoromethyl)phenylacetic acid2-(4-(trifluoromethyl)phenyl)acetic acid2-[4-(trifluoromethyl)phenyl]acetic acid
Show more names
AKOS BBS-00006832RARECHEM AL BO 0136TIMTEC-BB SBB000434TrifluoroMethyl on acid4-(Trifluoromethyl)Phenylaceti2-(4-(Trifluoromethyl)Phenyl)Acet(A,A,A-TRIFLUORO-P-TOLY)ACETIC ACID(α,α,α-Trifluoro-p-tolyl)acetic acid(à,à,à-trifluoro-p-tolyl)acetic acid
[4-(trifluoromethyl)phenyl]acetic acid4-Trifluoromethylphenylacetic acid(alpha,alpha,alpha-Trifluoro-p-tolyl)acetic acidMFCD00004352p-(TRIFLUOROMETHYL)PHENYLACETIC ACIDp-Trifluoromethylphenylacetic acid4-trifluoromethylphenyl acetic acid(4-trifluoromethyl-phenyl)acetic acid
Database identifiers
- CAS
32857-62-8- PubChem CID
- 118342
- DTXSID
DTXSID40186514- UNII
- WRH9JL4FEE
- EC Number
- 251-263-5
- Nikkaji
- J236.229E
Properties
Computed structural properties
- XLogP
- 2.4
- Topological polar surface area
- 37.3 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 2
- Heavy atoms
- 14
- Formal charge
- 0
- Complexity
- 205
Experimental & physicochemical properties
LogP2.45
Physicochemical properties
- Melting point
- 82 · 82-85 °C(lit.)
- Boiling point
- 203 °C · 203°C (rough estimate)
- Density
- 1.2815 · 1.2815 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.01 · 4.01±0.10(Predicted)
- form
- Crystals or Crystalline Powder
- color
- White to very pale yellow
- BRN
- 2267687 · 2267687
- InChI
- 1S/C9H7F3O2/c10-9(11,12)7-3-1-6(2-4-7)5-8(13)14/h1-4H,5H2,(H,13,14)
- InChIKey
- HNORVZDAANCHAY-UHFFFAOYSA-N
- SMILES
- OC(=O)Cc1ccc(cc1)C(F)(F)F
- CAS DataBase Reference
- 32857 · 32857-62-8(CAS DataBase Reference)
- FDA UNII
- 9 JL4FEE · WRH9JL4FEE
- NIST Chemistry Reference
- («ALPHA»,«alpha»,«alpha»-trifluoro-p-tolyl)-acetic acid(32857-62-8)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P264-P271-P280-P302+P352-P305+P351+P338
- target organs
- Respiratory system
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 26 · 26-37/39-36
- WGK Germany
- 3 · 3
- HazardClass
- IRRITANT
- HS Code
- 29163990 · 29163990
- Storage Class
- 11 · 11 - Combustible Solids
- Hazard Classifications
- 2 Skin · Eye Irrit. 2Skin Irrit. 2STOT SE 3
Safety & regulation
GHS classification
GHS Classification
Warning
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesSkin Irrit. 2 (100%)
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 3
- hs_code
- 29163990
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-37/39-36
- hazard_class
- IRRITANT
- Storage Class
- 11 - Combustible Solids
- target organs
- Respiratory system
- Hazard statements
- H315-H319-H335
- Hazard Classifications
- Eye Irrit. 2Skin Irrit. 2STOT SE 3
- Precautionary statements
- P261-P264-P271-P280-P302+P352-P305+P351+P338
Chemistry & industry
Applications
Uses4-(Trifluoromethyl)benzeneacetic Acid is an intermediate used to synthesize PPARγ/δ dual agonists via solid-Phase parallel synthesis. It was also used to prepare heterocyclic xanthine derivatives as highly potent and selective human A2B adenosine receptor antagonists.
General Description4-(Trifluoromethyl)phenylacetic acid undergoes diolefination mediated by mono-N-protected amino acid ligands in the presence of ethyl acrylate, Pd(OAc)2, KHCO3 and t-amyl alcohol.
Upstream & downstream products
Upstream raw materials
Downstream products
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Related reactions
1,149 records
Compound notes
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