Completing data — refresh the page later to see the latest
Basic information
- CAS
154039-60-8- Standard SMILES
CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C- InChIKey
OCSMOTCMPXTDND-OUAUKWLOSA-N- Molecular formula
- C15H29N3O5
- Average molar mass
- 331.413 g/mol
- Monoisotopic mass
- 331.21072103
Names & identifiers
- Preferred name
- Marimastat
- IUPAC
- (2S,3R)-N~4~-[(2S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N~1~,2-dihydroxy-3-(2-methylpropyl)butanediamide
- English name
- Marimastat
- Molecular formula
- C15H29N3O5
- Molecular weight
- 331.41
Names & synonyms
TMHGI 5712BB 2516TA 2516CS-1627KB-R 8898MarimastatMarimistatMarimastat(BB-2516)BB 2516MARIMISTAT
Database identifiers
- CAS
154039-60-8- PubChem CID
- 119031
- DTXSID
DTXSID20165524- ChEMBL
CHEMBL279785- ChEBI
CHEBI:50662- UNII
- D5EQV23TDS
- Nikkaji
- J930.059G
Properties
Physicochemical properties
- Melting point
- 148 ℃ · 148℃
- Density
- 1.14 · 1.140±0.06 g/cm3(Predicted)
- RTECS
- 6665000 · EJ6665000
- storage temp.
- -20 °C · -20°C
- solubility
- 20 mg/mL · DMSO: ≥20mg/mL
- form
- White solid
- pka
- 9.44 · 9.44±0.40(Predicted)
- color
- White to gray
- InChI
- 1S/C15H29N3O5/c1-8(2)7-9(10(19)13(21)18-23)12(20)17-11(14(22)16-6)15(3,4)5/h8-11,19,23H,7H2,1-6H3,(H,16,22)(H,17,20)(H,18,21)/t9-,10+,11-/m1/s1
- InChIKey
- OCSMOTCMPXTDND-OUAUKWLOSA-N
- SMILES
- CNC(=O)[C@@H](NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO)C(C)(C)C
- NCI Dictionary of Cancer Terms
- marimastat
- FDA UNII
- 5 EQV23TDS · D5EQV23TDS
- NCI Drug Dictionary
- marimastat
- UNSPSC Code
- 12352200 · 12352200
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P280a-P304+P340-P305+P351+P338-P405-P501a
- WGK Germany
- 3 · 3
- HS Code
- 29241990 · 29241990
- Storage Class
- 11 · 11 - Combustible Solids
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- hs_code
- 29241990
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Chemistry & industry
Applications
UsesAntineoplastic (matrix metalloproteinase inhibitor).
UsesMarimastat acts as a matrix metalloproteinase inhibitor in the treatment of various cancers, and pathological occurrences such as arthritis and atherosclerosis.
UsesMarimastat has been used as an inhibitor of:metalloproteinase 2/9 (MMP2/9), to study its effects on exercise-mediated interleukin-6 (IL-6) release in micemetalloproteinase, to determine protease activity in Pseudomonas aeruginosa culturesmetalloproteinase 10 (MMP10), to study its effect on monoclonal antibody H3 binding to MMP10
General DescriptionAn orally active peptidyl hydroxamate-based broad-spectrum MMP inhibitor (IC50 in nM = 5, 6, 200, 20, 2, 1.8 and 3.8 for MMP-1, -2, -3, -7, -8, -14 and TACE, respectively) that targets both the substrate binding site and the active-site Zn2+. Marimastate is widely used in studying the involvement of MMPs in various cellular and pathological processes both in vitro and in vivo.
Suppliers97 total
北京华美互利生物化工010-56205725 · [email protected]
南通飞宇生物科技有限公司0513-68819626 15152877458 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
杭州鼎燕化工有限公司13588754826 13588754826 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…