Silicon phthalocyanine
Basic information
- CAS
135719-28-7- Standard SMILES
CN(C)CCC[Si](C)(C)[O-].[OH-].[Si+4].c1ccc2c(c1)-c1cc3nc(nc4[n-]c(nc5[n-]c(nc-2n1)c1ccccc51)c1ccccc41)-c1ccccc1-3- InChIKey
JACPFCQFVIAGDN-UHFFFAOYSA-M- Molecular formula
- C40H36N8O2Si2
- Average molar mass
- 716.9 g/mol
- Monoisotopic mass
- 716.24997549
Overview
Silicon Phthalocyanine 4 is a synthetic photosensitizer agent containing a large macrocyclic ring chelated with silicon. Silicon phthalocyanine 4 localizes primarily in mitochondrial cytosolic membranes and, after photoexcitation, forms reactive oxygen species that induce apoptosis.
Names & identifiers
- Preferred name
- Silicon phthalocyanine
- IUPAC
- 3-[dimethyl(oxido)silyl]-N,N-dimethylpropan-1-amine;2,11,20,37,38-pentaza-39,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19,21(38),22,24,26,28,30(37),31,33,35-nonadecaene;silicon(4+);hydroxide
- English name
- silicon phthalocyanine
- Molecular formula
- C40H36N8O2Si2
- Molecular weight
- 716.93724
Names & synonyms
Silicon phthalocyanineSipc IV135719-28-7Cl2SiPcHosipcosi(CH3)2(CH2)3N(CH3)2DTXSID00159502Silicon, ((3-(dimethylamino)propyl)dimethylsilanolato-kappaO)hydroxy(29H,31H-phthalocyaninato(2-)-kappaN29,kappaN30,kappaN31,kappaN32)-, (OC-6-23)-RefChem:183005DTXCID8081993Silicon Phthalocyanine 43-[dimethyl(oxido)silyl]-N,N-dimethylpropan-1-amine;2,11,20,37,38-pentaza-39,40-diazanidanonacyclo[28.6.1.13,10.112,19.121,28.04,9.013,18.022,27.031,36]tetraconta-1,3,5,7,9,11,13,15,17,19,21(38),22,24,26,28,30(37),31,33,35-nonadecaene;silicon(4+);hydroxideUNII-VM2R9Z8DTW
Show more names
Nsc676418Siliconphthalocyanine4Silicone phthalocyanineSilicon,[[3-(dimethylamino)propyl]dimethylsilanolato-kO]hydroxy[29H,31H-phthalocyaninato(2-)-kN29,kN30,kN31,kN32]-, (OC-6-23)- (9CI)
Silicon phthalocyanine Pc4(OC-6-23)-((3-(Dimethylamino)propyl)dimethylsilanolato-O)hydroxy(29H,31H-phthalocyaninato(2-)-N(29),N(30),N(31),N(32))siliconNSC 676418Silicon, ((3-(dimethylamino)propyl)dimethylsilanolato-O)hydroxy(29H,31H-phthalocyaninato(2-)-N(29),N(30),N(31),N(32))-, (OC-6-23)-
Properties
Computed structural properties
- Topological polar surface area
- 93.8 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 10
- Rotatable bonds
- 4
- Heavy atoms
- 52
- Formal charge
- 0
- Complexity
- 939
Physicochemical properties
- NCI Dictionary of Cancer Terms
- 4 · silicon phthalocyanine 4
- FDA UNII
- 2 R9Z8DTW · VM2R9Z8DTW
- NCI Drug Dictionary
- 4 · silicon phthalocyanine 4
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.
Applications
UsesPhotosensitizer Pc 4 (NSC-676418) is a photosensitizer, which inhibits Plasmodium falciparum in dark or under red light by disturbing the protein/DNA synthesis, with an IC50 of 24 nM[1].
Related reactions
0 records
No reaction records under the current filter.
Compound notes
Loading…