Basic information
- CAS
496-00-4- Standard SMILES
N=C(N)c1ccc(OCCCOc2ccc(C(=N)N)cc2Br)c(Br)c1- InChIKey
GMJFVGRUYJHMCO-UHFFFAOYSA-N- Molecular formula
- C17H18Br2N4O2
- Average molar mass
- 470.2 g/mol
- Monoisotopic mass
- 467.97965
Overview
Dibrompropamidine is an aromatic ether.
Names & identifiers
- Preferred name
- Dibrompropamidine
- IUPAC
- 3-bromo-4-[3-(2-bromo-4-carbamimidoylphenoxy)propoxy]benzenecarboximidamide
- English name
- Dibrompropamidine
- Molecular formula
- C17H18Br2N4O2
- Molecular weight
- 470.16
Names & synonyms
DibrompropamidineDibromopropamidine496-00-4DibromopropamidinaDibrompropamidinumdibrompropamidina269M3QL74SDTXSID901979184,4'-(Trimethylenedioxy)bis(3-bromobenzamidine)3-bromo-4-[3-(2-bromo-4-carbamimidoylphenoxy)propoxy]benzene-1-carboximidamide3-bromo-4-(3-(2-bromo-4-carbamimidoylphenoxy)propoxy)benzene-1-carboximidamideRefChem:132915
Show more names
4,4'-(Trimethylenebisoxy)bis(3-bromobenzamidine)4,4'-[1,3-Propanediylbisoxy]bis(3-bromobenzamidine)4,4'-[1,3-Propanediylbis(oxy)]bis(3-bromobenzamidine)Benzenecarboximidamide, 4,4'-[1,3-propanediylbis(oxy)]bis[3-bromo-
D08AC01DTXCID50120409S01AX14Dibrompropamidine [INN]3-bromo-4-[3-(2-bromo-4-carbamimidoylphenoxy)propoxy]benzenecarboximidamideCHEMBL30044Dibrompropamidine (INN)NCGC00189076-01
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 3.2
- Topological polar surface area
- 118 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 8
- Heavy atoms
- 25
- Formal charge
- 0
- Complexity
- 426
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Biocides/Disinfectants
Physicochemical properties
- FDA UNII
- 269 M3QL74S · 269M3QL74S
- ATC code
- 8 AC01,S01AX14 · D08AC01,S01AX14
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Toxicology
Treatment
EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
Health Effects
Bromine vapour causes irritation and direct damage to the mucous membranes. Elemental bromine also burns the skin. The bromide ion is a central nervous system depressant and chronic exposure produces neuronal effects. This is called bromism and can result in central reactions reaching from somnolence to coma, cachexia, exicosis, loss of reflexes or pathologic reflexes, clonic seizures, tremor, ataxia, loss of neural sensitivity, paresis, papillar edema of the eyes, abnormal speech, cerebral edema, delirium, aggressiveness, and psychoses. (L625, L626, L627)
Exposure RoutesOral (L626) ; inhalation (L626) ; dermal (L626)
Toxicity Summary
Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and produce tissue damage. In additon, the formation of hydrobromic and bromic acids will result in secondary irritation. The bromide ion is also known to affect the central nervous system, causing bromism. This is believed to be a result of bromide ions substituting for chloride ions in the in actions of neurotransmitters and transport systems, thus affecting numerous synaptic processes. (L626, L627, A543)
Signs and Symptoms
Bromine vapour causes irritation and direct damage to the mucous membranes. Symptoms include lacrimation, rhinorrhoea, eye irritation with mucous secretions from the oropharyngeal and upper airways, coughing, dyspnoea, choking, wheezing, epistaxis, and headache. The bromide ion is a central nervous system depressant producing ataxia, slurred speech, tremor, nausea, vomiting, lethargy, dizziness, visual disturbances, unsteadiness, headaches, impaired memory and concentration, disorientation and hallucinations. This is called bromism. (L626, L627)
Chemistry & industry
Pharmacology
ATC Code
S - Sensory organs
D - Dermatologicals
QD - Dermatologicals
QS - Sensory organs
Metabolism/Metabolites
Bromine is mainly absorbed via inhalation, but may also enter the body through dermal contact. Bromine salts can be ingested. Due to its reactivity, bromine quickly forms bromide and may be deposited in the tissues, displacing other halogens. (L626)
MeSH Pharmacological ClassificationSubstances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Uses & manufacturing
Uses
Dibromopropamidine isethionate is used as an antiseptic, antiamebic, and cosmetic preservative; [Merck Index]
Using Disinfectants or Biocides [Category: Clean]
As dibrompropamidine isethionate, it is also used in eyedrops and ointment for the treatment of infections. Diatomic bromine does not occur naturally, but bromine salts can be found in crustal rock.
Upstream & downstream products
Upstream raw materials
Suppliers2 total
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
湖北清北云研医药科技有限责任公司
Related reactions
2 records
Compound notes
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