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Basic information
- CAS
88768-40-5- Standard SMILES
CCOC(=O)[C@H](CCc1ccccc1)N[C@@H]1CCCN2CCC[C@@H](C(=O)O)N2C1=O- Molecular formula
- C22H31N3O5
- Average molar mass
- 417.5 g/mol
Names & identifiers
- Preferred name
- Cilazapril
- English name
- Cilazapril
- Molecular formula
- C22H31N3O5
- Molecular weight
- 417.5
Names & synonyms
Vascace(1S,9S)-YipingshuRo34-2848CilazaprilRo 31-2848Ro 34-2848Ro-34-2848CILASTATIN NACilazapril USP/EP/BP
Database identifiers
- CAS
88768-40-5- PubChem CID
- 122173003
- EC Number
- 641-006-9
Properties
Physicochemical properties
- Melting point
- 95 · 95-97°C
- Boiling point
- 598.1 · 598.1±60.0 °C(Predicted)
- Density
- 1.26 · 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly)
- form
- powder
- pka
- 2.28 · 2.28±0.20(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 88768 · 88768-40-5(CAS DataBase Reference)
- FDA UNII
- 8 Q9454114Q · 8Q9454114Q
- ATC code
- 9 AA08 · C09AA08
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P280-P301+P312-P302+P352-P305+P351+P338
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 3 · 3
- RTECS
- 9650200 · MJ9650200
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- rtecs
- MJ9650200
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P280-P301+P312-P302+P352-P305+P351+P338
Chemistry & industry
Applications
DescriptionCilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat. In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.
UsesAn ACE inhibitor. Hydrolyzed in vivo to the active diacid metabolite (Cilazaprilat). Antihypertensive.
Suppliers34 total
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
奥夫仑医药（四川）有限公司17336178085 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
陕西缔都化学有限公司029-029-81123119 17391733320 · [email protected]
重庆康洲智通医药科技有限公司173-08362167 17308362167 · [email protected]
LGM Pharma1-(800)-881-8210 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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