Basic information
- CAS
625-45-6- Standard SMILES
COCC(=O)O- InChIKey
RMIODHQZRUFFFF-UHFFFAOYSA-N- Molecular formula
- C3H6O3
- Average molar mass
- 90.08 g/mol
- Monoisotopic mass
- 90.03169405
Overview
Methoxyacetic acid is a colorless liquid. (NTP, 1992)
Names & identifiers
- Preferred name
- Methoxyacetic Acid
- IUPAC
- 2-methoxyacetic acid
- English name
- Methoxyacetic acid
- Molecular formula
- C3H6O3
- Molecular weight
- 90.08
Names & synonyms
METHOXYACETIC ACID2-Methoxyacetic acid625-45-6Acetic acid, methoxy-Methoxyethanoic acidAcetic acid, 2-methoxy-DTXSID1031591F11T1H7Q7WNSC-7300DTXCID9011591CHEBI:132098RefChem:157058
Show more names
Methoxyacetic2-methoxyaceticMethoxyessigsuremethoxy-aceticaciMethoxyactic acidMethylglycolicacid
210-894-6CH3OCH2COOHmethoxy-acetic acidMFCD00004308CAS-625-45-62-MethoxyaceticAcidCCRIS 6518Iopromide Impurity 45
Database identifiers
- CAS
625-45-6- PubChem CID
- 12251
- DTXSID
DTXSID1031591- ChEMBL
CHEMBL1697714- ChEBI
CHEBI:132098- UNII
- F11T1H7Q7W
- EC Number
- 210-894-6
- Nikkaji
- J502I
Properties
Computed structural properties
- XLogP
- -0.3
- Topological polar surface area
- 46.5 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 2
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 50
Experimental & physicochemical properties
Chemical Classes
Other Classes -> Organic Acids
Industrial compound
SpringerMaterials PropertiesBoiling point
Density1.177 at 68 °F (NTP, 1992) - Denser than water; will sink
Solubility
greater than or equal to 100 mg/mL at 66 °F (NTP, 1992)
1000 mg/mL at 20 °C
Flash Point
greater than 235 °F (NTP, 1992)
Flash Point > 235 °F
Endocrine DisruptorsPotential endocrine disrupting compound
Boiling Point397 to 399 °F at 760 mmHg (NTP, 1992)
Melting Point
45.9 °F (NTP, 1992)
7.7 °C
Vapor Pressure1 mmHg at 126.5 °F ; 40 mmHg at 252 °F; 400 mmHg at 363.6 °F (NTP, 1992)
Physical Description
Methoxyacetic acid is a colorless liquid. (NTP, 1992)
Liquid
Colorless liquid; [CAMEO]
Liquid
Physicochemical properties
- Melting point
- 7 · 7-9 °C (lit.)
- Boiling point
- 202 · 202-204 °C (lit.)
- Density
- 1.174 g/mL · 1.174 g/mL at 25 °C (lit.)
- refractive index
- 20 · n20/D 1.417(lit.)
- Flash point
- 230 °F · >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol (Slightly); Soluble in water, alcohol and oils.
- form
- Liquid
- pka
- 1 · pK1:3.57 (25°C)
- color
- Clear colorless to very slightly yellow
- PH
- 1.6 · 1.6 (100g/l, H2O)
- Odor
- Peculiar fatty vinegear-like odor, in dilution fairly pleasant.
- Water Solubility
- freely soluble
- Sensitive
- Hygroscopic
- BRN
- 635800 · 635800
- Henry's Law Constant
- 1.5 · 1.5×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
- InChI
- 1S/C3H6O3/c1-6-2-3(4)5/h2H2,1H3,(H,4,5)
- InChIKey
- RMIODHQZRUFFFF-UHFFFAOYSA-N
- SMILES
- COCC(O)=O
- LogP
- -0.68 · -0.68
- Substances of Very High Concern (SVHC) Candidate List
- Methoxyacetic acid (625-45-6)
- CAS DataBase Reference
- 625 · 625-45-6(CAS DataBase Reference)
- EWG's Food Scores
- 3 · 3
- FDA UNII
- 11 T1H7Q7W · F11T1H7Q7W
- NIST Chemistry Reference
- Acetic acid, methoxy-(625-45-6)
- EPA Substance Registry System
- Methoxyacetic acid (625-45-6)
- UNSPSC Code
- 12352100 · 12352100
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 5 · GHS05,GHS07,GHS08
- Signal word
- Danger
- Hazard statements
- 302 · H302-H314-H335-H360FD
- Precautionary statements
- 201 · P201-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
- target organs
- Respiratory system
- PPE
- Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
- Hazard Codes
- T
- Risk Statements
- 60 · 60-61-22-34
- Safety Statements
- 53 · 53-45
- RIDADR
- 3265 · UN 3265 8/PG 2
- WGK Germany
- 1 · 1
- RTECS
- 8650000 · AI8650000
- F
- 10 · 10-21
- TSCA
- TSCA listed
- HazardClass
- 8 · 8
- PackingGroup
- II
- HS Code
- 29189090 · 29189090
- Storage Class
- 6.1 C · 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard Classifications
- 4 OralEye · Acute Tox. 4 OralEye Dam. 1Repr. 1BSkin Corr. 1BSTOT SE 3
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
Danger
H302: Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P318, P321, P330, P363, P405, and P501 (click each P-code to see the statement)
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P264, P264+P265, P270, P273, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P318, P321, P330, P363, P405, and P501 (click each P-code to see the statement)
Hazard information
Regulatory Information
Chemical: Acetic acid, methoxy-
Hazard Traits - Reproductive Toxicity
Acetic acid, 2-methoxy- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Acetic acid, 2-methoxy- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 12-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/2127
Substance: Methoxyacetic acid
Methoxyacetic acid: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Acetic acid, methoxy-: Human health tier II assessment
DOT LabelCorrosive
Fire HazardsThis chemical is combustible. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: This compound is corrosive. (NTP, 1992)
Hazards SummaryMay cause burns; [eChemPortal: ESIS] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline]
Reactive GroupAcids, Carboxylic
Reactivity ProfileMETHOXYACETIC ACID is incompatible with alkalis and metals. (NTP, 1992)
Air and Water ReactionsHygroscopic. Water soluble.
Hazard Classes and Categories
Acute Tox. 4 (100%)
Acute toxicity - category 4
Acute toxicity (Oral) - Category 4
Repr. 1B
Safety & protection
Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
Exposure Control and Personal Protection1.0 [ppm]
Nonfire Spill ResponseSTORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)
Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:
Personal Protective Equipment (PPE)MINIMUM PROTECTIVE CLOTHING: If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.
Toxicology
Adverse EffectsDermatotoxin - Skin burns.
Safety data
- F
- 10-21
- PPE
- Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- AI8650000
- ridadr
- UN 3265 8/PG 2
- hs_code
- 29189090
- risk_code
- 60-61-22-34
- Signal word
- Danger
- Symbol(GHS)
- GHS05,GHS07,GHS08
- hazard_code
- T
- safety_code
- 53-45
- hazard_class
- 8
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- packing_group
- II
- target organs
- Respiratory system
- Hazard statements
- H302-H314-H335-H360FD
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 4 OralEye Dam. 1Repr. 1BSkin Corr. 1BSTOT SE 3
- Precautionary statements
- P201-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Uses & manufacturing
UsesUsed in organic synthesis; [Hawley]
U.S. Production2023: 1,000,000 - <8,500,000 lb
Industry UsesOther
Household ProductsInformation on 3 consumer products that contain Methoxyacetic acid in the following categories is provided:
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
Acetic acid, 2-methoxy-: ACTIVE
Applications
UsesMethoxyacetic acid is used in zebrafish embryotoxicity test to evaluate chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis. It is also used in industry as gelling, viscosity and stabilizer reagent.
General DescriptionColorless liquid.
Upstream & downstream products
Downstream products
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
韶远科技（上海）有限公司021-50795510 4000665055 · [email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
北京华威锐科化工有限公司0757-86329057 18934348241 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
山东洛克化工有限公司17653113209 13065062079 · [email protected]
上海景颜化工科技有限公司13817811078 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
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上海思域化工科技有限公司86-21-34053660 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
上海健超生物科技有限公司150-2103-5486 18017383231 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
越林试剂021-62960152 · [email protected]
北京环宇世纪化学科技有限公司hysj_bj.com
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
上海将来实业股份有限公司021-61552785 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
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成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
湖南华腾制药有限公司400-8592883 · [email protected]
上海御略医药科技有限公司021-60345187 13671753212 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
上海嵩爰化工科技有限公司010-1234567 18521000990 · [email protected]
上海有朋化工有限公司021-69005955 13701776567 · [email protected]
江苏艾康生物医药研发有限公司025-66028182 17714375163 · [email protected]
上海凯赛化工有限公司021-33516722 13701817765 · [email protected]
上海彤源化工有限公司021-021-69182866 13701855675 · [email protected]
上海孚一生物科技有限公司+86 (21) 61124340
上海容立化学科技有限公司021-69992220 13701886816 · [email protected]
上海康拓化工有限公司021-69185552 13701777608 · [email protected]
池州凯隆进出口贸易有限公司[email protected]
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司021-61415566 800-8193336 · [email protected]
TargetMol中国（陶术生物）021-021-33632979 15002134094 · [email protected]
成都瑞欧克科技有限公司028-64353063 · [email protected]
Additional notes
DefinitionChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group.
Related reactions
310 records
Compound notes
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