CAS 625-50-3 Ethylacetamide (HCID 12253)

Overview

N-ethylacetamide is a member of the class of acetamides that is the N-ethyl derivative of acetamide. It has a role as a metabolite.

Names & identifiers

Preferred name: Ethylacetamide
IUPAC: N-ethylacetamide
English name: N-Ethylacetamide
Molecular formula: C4H9NO
Molecular weight: 87.12

Names & synonyms

N-ETHYLACETAMIDE625-50-3Acetamide, N-ethyl-AcetamidoethaneEthylacetamideAcetoethylamideM9Y95ZE6J9NSC-406307DTXSID5060803CHEBI:87370RefChem:163333DTXCID7043370

Show more names

acetylethylaminen-ethyl-acetamid

210-896-7N-AcetylethylamineN-AethylacetamidN-Ethyl-acetamideMFCD00009029N-ethylethanamideBRN 0969292UNII-M9Y95ZE6J9

Database identifiers

CAS: 625-50-3
PubChem CID: 12253
DTXSID: DTXSID5060803
ChEBI: CHEBI:87370
UNII: M9Y95ZE6J9
EC Number: 210-896-7
Nikkaji: J26.738D

Properties

Computed structural properties

XLogP: -0.1
Topological polar surface area: 29.1 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 1
Rotatable bonds: 1
Heavy atoms: 6
Formal charge: 0
Complexity: 51.5

Experimental & physicochemical properties

SolventsSolvents -> Amides (<C10)

SpringerMaterials PropertiesDensity

Boiling Point205.00 °C. @ 760.00 mm Hg

Physical DescriptionColorless or pale yellow liquid; [Alfa Aesar MSDS]

Physicochemical properties

Melting point: -32 °C · -32°C
Boiling point: 90 · 90-92 °C/8 mmHg (lit.)
Density: 0.924 g/mL · 0.924 g/mL at 25 °C (lit.)
refractive index: 20 · n20/D 1.433(lit.)
Flash point: 224 °F · 224 °F
storage temp.: Sealed in dry,Room Temperature
form: clear liquid
pka: 16.62 · 16.62±0.46(Predicted)
color: Colorless to Almost colorless
Water Solubility: Fully misicible in water.
BRN: 969292 · 969292
InChI: 1S/C4H9NO/c1-3-5-4(2)6/h3H2,1-2H3,(H,5,6)
InChIKey: PMDCZENCAXMSOU-UHFFFAOYSA-N
SMILES: CCNC(C)=O
LogP: -0.52 · -0.520 (est)
CAS DataBase Reference: 625 · 625-50-3(CAS DataBase Reference)
FDA UNII: 9 Y95ZE6J9 · M9Y95ZE6J9
NIST Chemistry Reference: Acetamide, N-ethyl-(625-50-3)
EPA Substance Registry System: Acetamide, N-ethyl- (625-50-3)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 7 · GHS07
Signal word: Warning
Hazard statements: 302 · H302
Precautionary statements: 280 · P280-P305+P351+P338
Hazard Codes: Xn
Risk Statements: 22 · 22
Safety Statements: 23 · 23-24/25
WGK Germany: 3 · 3
RTECS: 8500000 · AB8500000
TSCA: TSCA listed
HS Code: 29241990 · 29241990
Storage Class: 10 · 10 - Combustible liquids
Hazard Classifications: 4 Oral · Acute Tox. 4 Oral
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 145 reports by companies from 1 notifications to the ECHA C&L Inventory.

Hazard information

Regulatory Information · 3 items

Chemical: Acetamide, N-ethyl-

Status: Active Update: 13-12-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/30275

N-Ethylacetamide: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummaryCauses somnolence in intraperitoneal lethal-dose studies of mice (LD50 = 3,560 mg/kg); [RTECS] May cause irritation; [Alfa Aesar MSDS] See Dimethyl acetamide.

Hazard Classes and CategoriesAcute Tox. 4 (100%)

Toxicology

Adverse EffectsNeurotoxin - Acute solvent syndrome

Safety data

wgk: 3
tsca: TSCA listed
rtecs: AB8500000
hs_code: 29241990
risk_code: 22
Signal word: Warning
Symbol(GHS): GHS07
hazard_code: Xn
safety_code: 23-24/25
Storage Class: 10 - Combustible liquids
Hazard statements: H302
REACH Registrations: Active
Hazard Classifications: Acute Tox. 4 Oral
Precautionary statements: P280-P305+P351+P338

Chemistry & industry

Pharmacology

Cellular LocationsCytoplasm

Uses & manufacturing

General Manufacturing InformationAcetamide, N-ethyl-: ACTIVE

Applications · 3 items

UsesN-ethylacetamide is a suitable nylon model for mechanistic studies of dye fading. N-Ethylacetamide was used to investigate propylene carbonate and a mixture of N-methylformamide and N-ethylacetamide by broadband dielectric and mechanical shear spectroscopy. It was used in determination of reaction products of OH-oxidation of N-methylpyrrolidone under atmospheric conditions.

UsesN-Ethylacetamide was used to investigate propylene carbonate and a mixture of N-methylformamide and N-ethylacetamide by broadband dielectric and mechanical shear spectroscopy. It was used in determination of reaction products of OH-oxidation of N-methylpyrrolidone under atmospheric conditions.

General DescriptionN-Ethylacetamide is a suitable nylon model for mechanistic studies of dye fading.