HuagongsheHuagongshe Chemistry Print Report · For research reference only
beta-Mercapto-beta,beta-cyclopentamethylene-propionyl-Tyr(Et)-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2
sk&f100398 · d(CH2)5Tyr(Et)VAVP · M.W. 1136.41 C53H77N13O11S2 · [d(CH2)5,Tyr(Et)2,Val4]arginine vasopressin · (D(CH2)(5/1),TYR(ET)2,VAL4,ARG8)-VASOPRESSIN · (B-MERCAPTO-B,B-CYCLOPENTAMETHYLENE-*PRO PIONYL1,O-E · vasopressin 1-(1-MCHA)-2-(O-ethyl-L-tyrosine)-4-L-valine · [1-MERCAPTOCYCLOHEXYL]ACETYL-TYR[O-ETHYL]-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
Identifiers & Physical Properties
| CAS No. | 77453-01-1 |
|---|---|
| Molecular formula | C53H77N13O11S2 |
| Average molar mass | 1,136.39 g/mol |
| SMILES | CCOc1ccc(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@@H](C(=O)N3CCC[C@H]3C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc3ccccc3)NC2=O)cc1 |
| PubChem CID | 123741 |
| EC No. | 636-082-5 |
Chemical & Physical Properties
| Storage conditions | −20°C |
|---|---|
| Physical state | Solid |
| Color | White to off-white |
| Sequence | {(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6) |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H332 |
| GHS precautionary statements | P261-P271-P304+P340+P312 |
| Hazard symbols | Xn |
| Risk statements (R) | 20 |
| Safety statements (S) | 36 |
| Water hazard class (WGK) | 3 |
Safety & Regulations
| Water hazard class (WGK) | 3 |
|---|---|
| Risk statements (R) | 20 |
| Signal word | Warning |
| GHS pictogram | GHS07 |
| Hazard symbols | Xn |
| Safety statements (S) | 36 |
| GHS hazard statements | H332 |
| GHS precautionary statements | P261-P271-P304+P340+P312 |
Applications & Uses
Uses
SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP[1].